补充甲基萘醌-7 （MK-7）对人体测量、血糖指数和脂质谱的影响：随机对照试验的系统评价和荟萃分析

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Prostaglandins & other lipid mediators Pub Date : 2025-03-01 DOI:10.1016/j.prostaglandins.2025.106970

Omid Nikpayam , Ali Jafari , Amirhossein Faghfouri , Mohammadjavad Pasand , Pardis Noura , Marziyeh Najafi , Golbon Sohrab

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引用次数: 0

摘要

背景：与其他类型的维生素K相比，甲基萘醌-7 （MK-7）是一种半衰期更长、在体内停留时间更长的维生素K。最近，这种维生素对体重、血糖控制和脂质谱的影响引起了人们的广泛关注。综述的目的：本系统综述和荟萃分析旨在评估MK-7对人体测量、血糖指数和脂质谱的影响。方法：在PubMed、Scopus、Web of Science、谷歌Scholar等截止到2023年10月的电子数据库中，通过合适的关键词进行系统检索，获取相关原创文章。使用Cochrane协作工具评估研究的质量。六篇符合我们标准的原创文章被纳入分析。结果：经统计分析，MK-7对菊粉有较好的效果(SMD= -0.56；95% ci: -0.77, -0.36；P=0.000, I2= 84%， P=0.000), HbA1c (SMD=-0.32；95% ci: -0.55, -0.09；P=0.007, I2= 86.8%， P=0.000)，以及胰岛素抵抗稳态模型评估（HOMA-IR） (SMD= -0.56；95% ci: -0.76, -0.35；P=0.000, i2 = 84.3%， P=0.000)。此外，亚组分析显示，在接受≤90mg MK-7治疗不足12周的男女患者中，MK-7对总胆固醇（TC）、胰岛素、HbA1c和HOMA-IR的影响可以忽略不计。然而，MK-7对其他因素没有显著影响。结论：基于本系统综述和荟萃分析的结果，MK-7可能对血糖控制和TC有有益作用，尽管需要进一步的高质量的原始研究来得出一致的结论。

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Effect of Menaquinone-7 (MK-7) Supplementation on Anthropometric Measurements, Glycemic Indices, and Lipid Profiles: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background

Menaquinone-7 (MK-7) is a type of vitamin K that has a longer half-life and stays in the body for a more extended period compared to other types of vitamin K. Recently, the effects of this vitamin on body weight, glycemic control, and lipid profiles have garnered much attention. Aim of the review: This systematic review and meta-analysis were performed to evaluate the effects of MK-7 on anthropometric measurements, glycemic indices, and lipid profiles.

Methods

A systematic search via appropriate keywords was conducted in electronic databases including PubMed, Scopus, Web of Science, and Google Scholar up to October 2023 to obtain relevant original articles. The quality of studies was evaluated using the Cochrane Collaboration tool. Six original articles met our criteria and were included in the analysis.

Results

Statistical analysis showed that MK-7 had a desirable effect on inulin (SMD= −0.56; 95 % CI: −0.77, −0.36; P = 0.000, I2 = 84 %, P = 0.000), HbA1c (SMD=-0.32; 95 % CI: −0.55, −0.09; P = 0.007, I2 = 86.8 %, P = 0.000), and homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (SMD= −0.56; 95 % CI: −0.76, −0.35; P = 0.000, I2 = 84.3 %, P = 0.000). Additionally, subgroup analysis revealed negligible effects of MK-7 on total cholesterol (TC), insulin, HbA1c, and HOMA-IR in both genders of patients who received ≤ 90 mg MK-7 for less than 12 weeks. However, MK-7 didn’t have any meaningful effect on other factors.

Conclusion

Based on the findings of the present systematic review and meta-analysis, MK-7 may have beneficial effects on glycemic control and TC, although further highly qualified original research is needed for a consistent conclusion.

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.