靶向因子XI/XIa的抗凝药物和凝血试验：我们迫切需要可靠的药效学数据。

IF 5.5 2区医学 Q1 HEMATOLOGY

Journal of Thrombosis and Haemostasis Pub Date : 2025-03-06 DOI:10.1016/j.jtha.2025.02.025

Isabelle Gouin-Thibault , Thomas Lecompte , Dominique Lasne

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引用次数: 0

摘要

正在开发的抗fxi /FXIa抗凝剂包括反义寡核苷酸、单克隆抗体和小分子。它们不需要常规监测，但鉴于其预期的广泛使用，了解它们对凝血试验的影响是必不可少的。活化部分凝血活酶时间的浓度依赖性延长已被证明，但根据试剂的不同而不同，缺乏全面的数据使得解释这个测试很困难。FXI凝血活性的测量仅在反义寡核苷酸治疗的情况下相关。如果需要，接触途径因子的测量应在多次稀释血浆样品后进行，以克服抗凝剂的任何抑制作用。临床试验中使用的所有其他检测（FXIa、FXI抗原法、特异性凝血酶生成测定）均未在临床实验室实施。迫切需要关于抗fxi /FXIa抗凝剂对凝血试验影响的更全面的信息，以预测这些药物一旦获得批准后的使用情况。

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Anticoagulant drugs targeting factor XI/XIa and coagulation tests: we urgently need reliable pharmacodynamic data

Antifactor (F)XI/FXIa anticoagulants under development include antisense oligonucleotides, monoclonal antibodies, and small molecules. They do not require routine monitoring, but knowledge of their impact on coagulation tests is essential in view of their expected widespread use. A concentration-dependent prolongation of activated partial thromboplastin time has been shown but varies according to reagents, and the lack of comprehensive data makes interpretation of this test difficult. Measurement of FXI clotting activity is relevant only in case of treatment with antisense oligonucleotides. Measurement of contact pathway factors, if required, should be performed after multiple dilutions of the plasma sample to overcome any inhibitory effect of the anticoagulant. All other tests used in clinical trials (FXIa, FXI antigenic method, and specific thrombin generation assay) are not implemented in clinical laboratories.

More comprehensive information on the effect of anti-FXI/FXIa anticoagulants on coagulation tests is urgently needed to anticipate the use of these drugs once they are approved.

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来源期刊

Journal of Thrombosis and Haemostasis 医学-外周血管病

CiteScore

24.30

自引率

3.80%

发文量

321

审稿时长

1 months

期刊介绍： The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.