韩国2型糖尿病患者终末期肾脏疾病负担:一项全国性流行病学研究

IF 6.8 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Diabetes & Metabolism Journal Pub Date : 2025-05-01 Epub Date: 2025-03-06 DOI:10.4093/dmj.2024.0443
Jwa-Kyung Kim, Han Na Jung, Bum Jun Kim, Boram Han, Ji Hye Huh, Eun Roh, Joo-Hee Kim, Kyung-Do Han, Jun Goo Kang
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引用次数: 0

摘要

背景:糖尿病患者是终末期肾病(ESKD)的高危人群,但新发ESKD的准确年度风险数据仍然有限。在韩国,ESKD的患病率和发病率比全球平均水平增长得更快。本研究旨在确定2012 - 2022年糖尿病状态下ESKD的发病率(IR)。方法:利用韩国国民健康保险服务中心的数据,我们计算了普通人群中新发ESKD的IR和风险比(HR)。根据糖尿病状态将个体分为非糖尿病、空腹血糖受损(IFG)和糖尿病持续时间。结果:在参与者中,67.6%为非糖尿病,22.3%为空腹血糖受损,10%为糖尿病。在韩国,非糖尿病患者ESKD的ir为139 /百万人(pmp), IFG患者为188 /百万人(pmp),糖尿病患者为632 /百万人(pmp)。结论:糖尿病病程延长会增加ESKD风险,尤其是在肾功能下降的情况下。即使在肾功能正常的患者中,长期糖尿病也会显著增加ESKD风险,而IFG仅在早期CKD的年轻患者中与风险升高相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Burden of End-Stage Kidney Disease by Type 2 Diabetes Mellitus Status in South Korea: A Nationwide Epidemiologic Study.

Backgruound: Patients with diabetes are known to be at high risk for end-stage kidney disease (ESKD), but the accurate annual risk data for new-onset ESKD is still limited. In South Korea, the prevalence and incidence of ESKD are increasing more rapidly compared to the global average. This study aimed to determine the incidence rate (IR) of ESKD by diabetes status from 2012 to 2022.

Methods: Using data from the Korean National Health Insurance Service, we calculated the IR and hazard ratio (HR) for newonset ESKD in the general population. Individuals were categorized based on diabetes status into nondiabetes, impaired fasting glucose (IFG), diabetes duration <5 and ≥5 years.

Results: Among the participants, 67.6% were nondiabetic, 22.3% had IFG, and 10% had diabetes. In Korea, the IRs of ESKD were 139 per million population (pmp) for nondiabetes, 188 pmp for IFG, 632 pmp for diabetes <5 years, and 3,403 pmp for diabetes ≥5 years. An advanced estimated glomerular filtration rate (eGFR) category was the strongest risk factor for ESKD development. However, even in patients with normal renal function, those with long-standing diabetes had a 14-fold higher risk of ESKD compared to nondiabetic individuals. The risk of ESKD associated with diabetes increased exponentially with declining renal function. Notably, IFG showed an increasing tendency for ESKD in younger patients (<65 years) with early-stage chronic kidney disease (CKD; eGFR ≥60 mL/min/1.73 m²).

Conclusion: Longer diabetes duration amplifies ESKD risk, particularly as renal function declines. Even in patients with normal renal function, long-standing diabetes significantly increases ESKD risk, while IFG is associated with elevated risk only in younger individuals with early-stage CKD.

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来源期刊
Diabetes & Metabolism Journal
Diabetes & Metabolism Journal Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
10.40
自引率
6.80%
发文量
92
审稿时长
52 weeks
期刊介绍: The aims of the Diabetes & Metabolism Journal are to contribute to the cure of and education about diabetes mellitus, and the advancement of diabetology through the sharing of scientific information on the latest developments in diabetology among members of the Korean Diabetes Association and other international societies. The Journal publishes articles on basic and clinical studies, focusing on areas such as metabolism, epidemiology, pathogenesis, complications, and treatments relevant to diabetes mellitus. It also publishes articles covering obesity and cardiovascular disease. Articles on translational research and timely issues including ubiquitous care or new technology in the management of diabetes and metabolic disorders are welcome. In addition, genome research, meta-analysis, and randomized controlled studies are welcome for publication. The editorial board invites articles from international research or clinical study groups. Publication is determined by the editors and peer reviewers, who are experts in their specific fields of diabetology.
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