PlasmaCell CAD：一种计算机辅助诊断软件工具，用于显微镜图像中的浆细胞识别和表征

IF 3.7 2区医学 Q2 COMPUTER SCIENCE, INFORMATION SYSTEMS

International Journal of Medical Informatics Pub Date : 2025-03-06 DOI:10.1016/j.ijmedinf.2025.105869

Rasoul Kasbgar , Alireza Vard

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引用次数: 0

摘要

背景与目的在多发性骨髓瘤的传统诊断过程中，病理学家使用显微镜筛选准备好的血液样本，检测、分类和计数浆细胞。这种手动方法耗时、费力，而且容易出现人为错误。因此，医学专家和研究人员对任何部分或完全自动化这一过程的工具都非常感兴趣。为了实现这一目标，我们开发了一种名为PlasmaCell CAD的软件工具，通过显微镜图像分析诊断多发性骨髓瘤癌症的有效细胞。方法在提出的软件中，为了检测和分割细胞，我们利用了通过利用圆变换来生成锚点而得到增强的Mask-RCNN模型。同时，我们使用SVM分类器对正常和异常的浆细胞进行识别。此外，我们为PlasmaCell CAD设计并开发了图形用户界面（GUI），以便用户能够更轻松地使用它。结果我们考虑了所提出的软件在公开可用数据集和本地收集数据集上的性能。实验结果证明了PlasmaCell CAD软件对浆细胞进行分割和分类的能力和效率，以及它的易用性。结论splasmacell CAD是一个免费的软件工具，可以很容易地下载并安装在任何运行Windows的计算机上。PlasmaCell CAD为用户提供了一个用户友好的图形用户界面，其中包含几个图像处理和可视化工具，可以加速诊断过程。鉴于有希望的结果，PlasmaCell CAD软件可以帮助病理学家诊断多发性骨髓瘤癌。

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PlasmaCell CAD: A computer-aided diagnosis software tool for plasma cell recognition and characterization in microscopic images

Background and objective

In the traditional diagnostic process for multiple myeloma cancer, a pathologist screens prepared blood samples using a microscope to detect, classify, and count plasma cells. This manual approach is time-consuming, exhausting, and prone to human errors. Consequently, medical experts and researchers are highly interested in any tool that partially or entirely automates this process. To achieve this goal, we developed a software tool called PlasmaCell CAD to analyze effective cells for diagnosing multiple myeloma cancers through microscopic images.

Methods

In the proposed software, to detect and segment cells, we exploit the Mask-RCNN model that has been enhanced by leveraging the circlet transform for the anchor generation. Also, we use the SVM classifier to identify normal and abnormal plasma cells in this software. Moreover, we designed and developed a graphical user interface (GUI) for the PlasmaCell CAD so that users would be able to work with it more easily.

Results

we considered the performance of the proposed software on both a publicly available dataset and a locally collected dataset. The experimental results demonstrated the capability and efficiency of PlasmaCell CAD software in segmenting and classifying plasma cells as well as its ease of use.

Conclusions

PlasmaCell CAD is a free software tool that can easily be downloaded and installed on any computers running Windows. PlasmaCell CAD provides a user-friendly GUI with several image processing and visualization facilities for the user that can accelerate the diagnosis process. In light of promising results, PlasmaCell CAD software can be useful to pathologists in helping to diagnose multiple myeloma cancer.

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来源期刊

International Journal of Medical Informatics 医学-计算机：信息系统

CiteScore

8.90

自引率

4.10%

发文量

217

审稿时长

42 days

期刊介绍： International Journal of Medical Informatics provides an international medium for dissemination of original results and interpretative reviews concerning the field of medical informatics. The Journal emphasizes the evaluation of systems in healthcare settings. The scope of journal covers: Information systems, including national or international registration systems, hospital information systems, departmental and/or physician''s office systems, document handling systems, electronic medical record systems, standardization, systems integration etc.; Computer-aided medical decision support systems using heuristic, algorithmic and/or statistical methods as exemplified in decision theory, protocol development, artificial intelligence, etc. Educational computer based programs pertaining to medical informatics or medicine in general; Organizational, economic, social, clinical impact, ethical and cost-benefit aspects of IT applications in health care.