Hajar Mazahery , Lucinda J Black , Alison Daly , Maja Banjac , Catherine P Bondonno , Liezhou Zhong , Lauren C Blekkenhorst , Jonathan M Hodgson , the Ausimmune Investigator Group, Eleanor Dunlop
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Higher dietary nitrate intake is associated with lower likelihood of first clinical diagnosis of central nervous system demyelination in Australian women
Dietary nitrate is a precursor to nitric oxide, for which plausible mechanisms exist for both beneficial and detrimental influences in first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to the diagnosis of multiple sclerosis (MS). Whether dietary nitrate has any role in FCD onset is unclear. We tested associations between nitrate intake from food sources (plant, vegetable, animal, processed meat, and unprocessed meat) and likelihood of FCD. We used data from the Ausimmune Study (264 cases, 474 controls) and logistic regression with full propensity score matching. In females, higher nitrate intake from plant-based foods (odds ratio [OR] per 60 mg/day = 0.50; 95 % confidence interval [CI] 0.31, 0.81; p = <0.01) and vegetables (OR per 60 mg/day = 0.39; 95 % CI 0.22, 0.70; p = <0.01), but not other sources, was statistically significantly associated with lower likelihood of FCD. In males, no associations were found between any source of nitrate intake and likelihood of FCD. Our results support further research to explore a possible beneficial role for plant-derived nitrate in people at higher risk of MS.
期刊介绍:
Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource.
A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.