IF 2.9 3区 医学 Q2 CLINICAL NEUROLOGY
Hajar Mazahery , Lucinda J Black , Alison Daly , Maja Banjac , Catherine P Bondonno , Liezhou Zhong , Lauren C Blekkenhorst , Jonathan M Hodgson , the Ausimmune Investigator Group, Eleanor Dunlop
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引用次数: 0

摘要

膳食中的硝酸盐是一氧化氮的前体,在中枢神经系统脱髓鞘(FCD)的首次临床诊断(多发性硬化症(MS)诊断的常见前兆)中,一氧化氮的有利和不利影响机制都是合理的。目前还不清楚膳食中的硝酸盐是否对 FCD 的发病有任何影响。我们测试了食物来源(植物、蔬菜、动物、加工肉类和未加工肉类)中硝酸盐摄入量与 FCD 发病可能性之间的关系。我们使用了澳大利亚免疫研究(264 例病例,474 例对照)的数据,并使用了带有完全倾向得分匹配的逻辑回归。在女性中,从植物性食物(每 60 毫克/天的几率比 [OR] = 0.50; 95 % 置信区间 [CI] 0.31, 0.81; p = <0.01)和蔬菜(每 60 毫克/天的几率比 [OR] = 0.39; 95 % 置信区间 [CI 0.22, 0.70; p = <0.01)中摄入的硝酸盐较高,而从其他来源摄入的硝酸盐较低,在统计学上与 FCD 发生的可能性显著相关。在男性中,没有发现任何来源的硝酸盐摄入量与患 FCD 的可能性有关。我们的研究结果支持进一步开展研究,探索植物源硝酸盐对多发性硬化症高危人群可能起到的有益作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Higher dietary nitrate intake is associated with lower likelihood of first clinical diagnosis of central nervous system demyelination in Australian women
Dietary nitrate is a precursor to nitric oxide, for which plausible mechanisms exist for both beneficial and detrimental influences in first clinical diagnosis of central nervous system demyelination (FCD), a common precursor to the diagnosis of multiple sclerosis (MS). Whether dietary nitrate has any role in FCD onset is unclear. We tested associations between nitrate intake from food sources (plant, vegetable, animal, processed meat, and unprocessed meat) and likelihood of FCD. We used data from the Ausimmune Study (264 cases, 474 controls) and logistic regression with full propensity score matching. In females, higher nitrate intake from plant-based foods (odds ratio [OR] per 60 mg/day = 0.50; 95 % confidence interval [CI] 0.31, 0.81; p = <0.01) and vegetables (OR per 60 mg/day = 0.39; 95 % CI 0.22, 0.70; p = <0.01), but not other sources, was statistically significantly associated with lower likelihood of FCD. In males, no associations were found between any source of nitrate intake and likelihood of FCD. Our results support further research to explore a possible beneficial role for plant-derived nitrate in people at higher risk of MS.
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来源期刊
CiteScore
5.80
自引率
20.00%
发文量
814
审稿时长
66 days
期刊介绍: Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.
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