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IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research Pub Date : 2025-04-01 Epub Date: 2025-02-22 DOI:10.14740/cr2050

Barbara C Okeke, Timothy Chrusciel, Mina M Benjamin

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引用次数: 0

摘要

背景：我们试图从一个大型医疗系统数据库中比较转甲状腺素心脏淀粉样变性（CA）患者与非缺血性心肌病（NICM）患者的长期预后：方法：使用 ICD 代码从 SSM 医疗保健系统的数据仓库中识别出患有 CA 或 NICM 的患者。纳入标准包括至少 6 个月的随访。研究结果包括心衰住院（HFH）、室性快速性心律失常（VTA）、植入式心脏除颤器（ICD）和起搏器（PM）置入。结果：我们发现了231名CA患者，其中4人患有心律失常：我们确定了 231 名 CA 患者和 462 名 NICM 患者，他们的年龄、种族和性别匹配。CA患者的外周血管疾病（48.5% 对 35.5%）和冠状动脉疾病（10.4% 对 6.1%）发病率较高。平均随访时间为 48.1 ± 33.1 个月。CA患者的HFH发生率较高（57.6%对46.1%），ICD发生率较低（1.7%对5.9%）。在多变量模型中，CA 患者发生 HFH 的几率明显更高（几率比：1.86；95% 置信区间：1.29 - 2.68）。Kaplan-Meier生存曲线显示，CA患者有更早出现HFH和更晚植入PM或ICD的趋势：在这项来自大型医疗系统数据库的回顾性研究中，与 NICM 相比，经甲状腺素 CA 患者的 HFH 发生率明显更高，发生 VTA 的几率相似，接受心内装置的可能性较低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Long-Term Clinical Outcomes in Patients With Transthyretin Cardiac Amyloidosis Versus Non-Ischemic Cardiomyopathy.

Background: We sought to compare the long-term outcomes in patients with transthyretin cardiac amyloidosis (CA) compared to those with non-ischemic cardiomyopathy (NICM) from a large healthcare system database.

Methods: Patients with CA or NICM were identified from SSM Healthcare System's data warehouse using ICD codes. Inclusion criteria included at least 6 months of follow-up. Outcomes studied were heart failure hospitalization (HFH), ventricular tachyarrhythmias (VTA), implantable cardiac defibrillator (ICD) and pacemaker (PM) placement. Multivariate logistic analysis and Kaplan-Meier survival curves were constructed.

Results: We identified 231 patients with CA and 462 with NICM, matched for age, race, and gender. CA patients had higher incidence of peripheral vascular disease (48.5% vs. 35.5%) and coronary artery disease (10.4% vs. 6.1%). Mean follow-up was 48.1 ± 33.1 months. CA patients had a higher rate of HFH (57.6% vs. 46.1%) and a lower rate of ICD (1.7% vs. 5.9%). In the multivariate model, CA patients had significantly higher odds for HFH (odds ratio: 1.86; 95% confidence interval: 1.29 - 2.68). Kaplan-Meier survival curves showed a trend toward earlier HFH and later PM or ICD implantation in CA patients.

Conclusions: In this retrospective study from a large healthcare system database, compared to NICM, transthyretin CA patients had significantly higher rates of HFH, similar odds of VTA, and a lower likelihood of receiving an intracardiac device.

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.