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IF 1.9 3区医学 Q3 CLINICAL NEUROLOGY

Acta Neurochirurgica Pub Date : 2025-03-08 DOI:10.1007/s00701-025-06424-8

Ingrid Løchen Granerud, Maria Louise Fabritius, Helene Ravnholt Jensen, Kirsten Møller, Martin Kryspin Sørensen

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引用次数: 0

摘要

背景脑内微透析是指导临床医生对严重急性脑损伤患者进行重症监护的先进方法。通过脑内微透析，可以分析脑代谢和平衡的标志物。目前，在临床决策中，趋势比绝对值更重要。确定健康脑组织的绝对参考值有助于更早地发现脑组织代谢异常，并为临床医生提供更好的决策支持。然而，目前关于未受伤人脑正常值的证据尚未总结。本研究的目的是总结有关人类和颅脑动物健康脑组织体内脑能量代谢常见标记物（葡萄糖、乳酸、丙酮酸、谷氨酸和甘油）微透析浓度的文献。为了确定未发表的研究，我们检索了ClinicalTrials.gov、WHO国际临床试验注册平台（ICTRP）和欧盟临床试验注册中心。结果在已确定的 3257 项研究中，有 39 项研究被纳入。其中 6 项研究以人为对象（总数 n = 54），26 项研究以猪/猪为对象（n = 432），2 项研究以猴为对象（n = 10），1 项研究以羊为对象（n = 15），1 项研究以狗为对象（n = 10）。我们发现人类和颅脑动物的研究在临床和方法上存在高度异质性。结论本范围界定综述确定了应用微透析测量健康脑组织中常见生物标记物的研究。测量值之间的临床和方法异质性很大，限制了任何结论的得出。此外，几项人体研究的质量充其量只能算中等。有必要进行方法上可比的研究，以便利用脑内微透析建立脑能量代谢标志物的参考值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Cerebral microdialysis values in healthy brain tissue – a scoping review

Background

Intracerebral microdialysis is an advanced method to guide clinicians during intensive care of patients with severe acute brain injury. Using intracerebral microdialysis, markers of brain metabolism and homeostasis can be analysed. Currently, trends are considered more important in clinical decision-making than absolute values. Establishing absolute reference values in healthy brain tissue may facilitate an earlier detection of abnormal brain tissue metabolism and provide better decision support for clinicians. However, the current evidence on normal values in the uninjured human brain has not previously been summarized. The aim of this study was to summarise the literature regarding microdialysate concentrations of common markers of brain energy metabolism (glucose, lactate, pyruvate, glutamate, and glycerol) in vivo in healthy brain tissue of humans and gyrencephalic animals.

Method

MEDLINE, Embase, CENTRAL, CINAHL, and Web of Science were searched for published studies that report values of microdialysis in healthy brain tissue. In order to identify unpublished studies, we searched ClinicalTrials.gov, WHO International Clinical Trials Registry Platform (ICTRP), and EU Clinical Trials Register. Study quality was evaluated using a pre-specified protocol.

Result

Out of 3257 studies identified, 39 studies were included. Six of these studies were in humans (total n = 54), 26 in pigs/swine (n = 432), two on monkeys (n = 10), one in sheep (n = 15), and one in dogs (n = 10). We found a high degree of clinical and methodological heterogeneity in both human and gyrencephalic animal studies.

Conclusion

This scoping review identified studies that applied microdialysis to measure common biomarkers in healthy brain tissue. The clinical and methodological heterogeneity between the measured values was substantial, limiting any conclusions. Furthermore, the quality of several human studies was moderate at best. Methodologically comparable studies are warranted to establish reference values for markers of brain energy metabolism using intracerebral microdialysate.

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来源期刊

Acta Neurochirurgica 医学-临床神经学

CiteScore

4.40

自引率

4.20%

发文量

342

审稿时长

1 months

期刊介绍： The journal "Acta Neurochirurgica" publishes only original papers useful both to research and clinical work. Papers should deal with clinical neurosurgery - diagnosis and diagnostic techniques, operative surgery and results, postoperative treatment - or with research work in neuroscience if the underlying questions or the results are of neurosurgical interest. Reports on congresses are given in brief accounts. As official organ of the European Association of Neurosurgical Societies the journal publishes all announcements of the E.A.N.S. and reports on the activities of its member societies. Only contributions written in English will be accepted.