坏死性胰腺炎并发结肠-横瘘的患者术后胰瘘发生率较高。

IF 2.1 3区医学 Q2 SURGERY

Langenbeck's Archives of Surgery Pub Date : 2025-03-06 DOI:10.1007/s00423-024-03578-4

Weiliang Tian, Tao Hu, Shikun Luo, Guoping Zhao, Risheng Zhao, Yunzhao Zhao, Qiurong Li, Zheng Yao, Qian Huang

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引用次数: 0

摘要

背景：本研究探讨感染性坏死性胰腺炎（INP）治疗期间开放性坏死性切除术（ON）的需要与横结肠瘘最终手术（DS）后胰瘘（POPF）的发展之间的关系。材料和方法：本研究在两家三级医院进行，纳入2009年1月至2023年12月因INP继发结肠瘘行DS的患者。患者随访至出院。主要观察指标为POPF的发生率。结果：共纳入135例患者。年龄中位数为38岁（四分位间距[IQR]: 32-44岁），男性85例（62.9%）。52例患者（38.5%）需要ON治疗，24例患者在ds后出现POPF。对ON的需求（优势比[OR] = 2.78, 95%可信区间[CI]: 1.03-7.58, p = 0.040）和INP分辨率到DS的间隔（OR = 0.82, 95% CI: 0.68-0.92, p = 0.011）与POPF相关。结论：在INP治疗期间需要ON与横结肠瘘管DS后POPF风险增加显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Postoperative pancreatic fistula is higher in patients with necrotizing pancreatitis who develop a colon-transverse fistula.

Background: This study explores the association between the need for open necrosectomy (ON) during infected necrotizing pancreatitis (INP) treatment and the development of postoperative pancreatic fistula (POPF) following definitive surgery (DS) for transverse colonic fistulas.

Materials and methods: This study was conducted at two tertiary hospitals and included patients who underwent DS for colonic fistula secondary to INP from January 2009 to December 2023. Patients were followed until hospital discharge. The primary outcome was the incidence of POPF.

Results: A total of 135 patients were included. The median age was 38 years (interquartile range [IQR]: 32-44 years), with 85 (62.9%) being male. ON was required in 52 patients (38.5%), with 24 patients developing POPF post-DS. The need for ON (odds ratio [OR] = 2.78, 95% confidence interval [CI]: 1.03-7.58, p = 0.040) and the interval from INP resolution to DS (OR = 0.82, 95% CI: 0.68-0.92, p = 0.011) were associated with POPF.

Conclusion: The need for ON during INP treatment is significantly associated with an increased risk of POPF following DS for transverse colonic fistulas.

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来源期刊

Langenbeck's Archives of Surgery 医学-外科

CiteScore

3.30

自引率

8.70%

发文量

342

审稿时长

4-8 weeks

期刊介绍： Langenbeck''s Archives of Surgery aims to publish the best results in the field of clinical surgery and basic surgical research. The main focus is on providing the highest level of clinical research and clinically relevant basic research. The journal, published exclusively in English, will provide an international discussion forum for the controlled results of clinical surgery. The majority of published contributions will be original articles reporting on clinical data from general and visceral surgery, while endocrine surgery will also be covered. Papers on basic surgical principles from the fields of traumatology, vascular and thoracic surgery are also welcome. Evidence-based medicine is an important criterion for the acceptance of papers.