The Multifaceted Effects of Berberine: Potential Uses in Dermatology.

Berberine is a natural alkaloid found in several plant species and has been utilized in traditional medicine for its antimicrobial, anti-inflammatory, and antioxidant properties. Berberine supplements are readily available over-the-counter in the United States. It has recently gained popularity on social media and is increasingly being used as complementary and alternative medicine. Berberine possesses a broad spectrum of pharmacological properties, which may be a result of its potent antioxidant properties and its regulatory effects on the gut microbiome. Acne, atopic dermatitis, pigmentary disorders, hidradenitis suppurativa, psoriasis, and skin aging are complex disorders, often requiring multifaceted treatment strategies. Berberine's broad mechanisms of action make it a promising candidate for the management of these conditions. This review explores the mechanisms of action of berberine and its clinical relevance in the management of dermatologic diseases. J Drugs Dermatol. 2025;24(3):298-301 doi:10.36849/JDD.8899.