一种分布导向的Mapper算法。

IF 2.9 3区 生物学 Q2 BIOCHEMICAL RESEARCH METHODS
Yuyang Tao, Shufei Ge
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引用次数: 0

摘要

背景:在拓扑数据分析中,Mapper算法是探索数据形状的重要工具。Mapper算法以一个数据集作为输入,输出一个表示整个数据集拓扑特征的图。这个图通常被认为是数据集的Reeb图的近似。经典的Mapper算法使用固定的间隔长度和重叠比率,这可能无法揭示数据集的微妙特征,特别是当底层结构很复杂时。结果:本文引入了一种名为D-Mapper的分布引导映射算法,该算法利用概率模型的性质和数据的内在特征来生成密度引导覆盖,并提供增强的拓扑特征。此外,我们还引入了一个度量重叠聚类质量和扩展持久同源性的度量来衡量mapper类型算法的性能。我们的数值实验表明,D-Mapper算法在各种场景下都优于经典的Mapper算法。我们还将D-Mapper应用于SARS-COV-2冠状病毒RNA序列数据集,以探索不同病毒变体的拓扑结构。结果表明,D-Mapper算法可以同时揭示病毒的垂直和水平进化过程。结论:D-Mapper算法可以基于概率模型从数据中生成覆盖。这项工作展示了融合概率模型与Mapper算法的力量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A distribution-guided Mapper algorithm.

Background: The Mapper algorithm is an essential tool for exploring the data shape in topological data analysis. With a dataset as an input, the Mapper algorithm outputs a graph representing the topological features of the whole dataset. This graph is often regarded as an approximation of a Reeb graph of a dataset. The classic Mapper algorithm uses fixed interval lengths and overlapping ratios, which might fail to reveal subtle features of a dataset, especially when the underlying structure is complex.

Results: In this work, we introduce a distribution-guided Mapper algorithm named D-Mapper, which utilizes the property of the probability model and data intrinsic characteristics to generate density-guided covers and provide enhanced topological features. Moreover, we introduce a metric accounting for both the quality of overlap clustering and extended persistent homology to measure the performance of Mapper-type algorithms. Our numerical experiments indicate that the D-Mapper outperforms the classic Mapper algorithm in various scenarios. We also apply the D-Mapper to a SARS-COV-2 coronavirus RNA sequence dataset to explore the topological structure of different virus variants. The results indicate that the D-Mapper algorithm can reveal both the vertical and horizontal evolutionary processes of the viruses. Our code is available at https://github.com/ShufeiGe/D-Mapper .

Conclusion: The D-Mapper algorithm can generate covers from data based on a probability model. This work demonstrates the power of fusing probabilistic models with Mapper algorithms.

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来源期刊
BMC Bioinformatics
BMC Bioinformatics 生物-生化研究方法
CiteScore
5.70
自引率
3.30%
发文量
506
审稿时长
4.3 months
期刊介绍: BMC Bioinformatics is an open access, peer-reviewed journal that considers articles on all aspects of the development, testing and novel application of computational and statistical methods for the modeling and analysis of all kinds of biological data, as well as other areas of computational biology. BMC Bioinformatics is part of the BMC series which publishes subject-specific journals focused on the needs of individual research communities across all areas of biology and medicine. We offer an efficient, fair and friendly peer review service, and are committed to publishing all sound science, provided that there is some advance in knowledge presented by the work.
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