激光切割纸中热解产物的识别与缓解

IF 3.1 2区 化学 Q2 BIOCHEMICAL RESEARCH METHODS
Magnus Rydberg, Alexis Ochoa, Katherine Dayana Barrera Campos, Christine Skaggs, Ashur Rael, Nicholas Manicke
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引用次数: 0

摘要

纸喷雾质谱(PS-MS)通常采用激光切割来制备纸基材,可能会引起纤维素骨架的局部热分解。本研究研究了纤维素热解产物和纸张中固有的背景分子如何影响PS-MS信号质量,并评估了纸张预处理方法以提高性能。用质谱和紫外可见光谱(UV-vis)对激光切割纸和剃刀切割纸进行对比分析,发现差异显著。激光切割后的纸张在200-400 nm紫外波段显示出更高的MS空白信号和更高的吸光度,表明化学丰度和复杂性增加。气相色谱-质谱联用(GC-MS)在激光切割纸上发现了20多种剃刀切割样品中没有的残留化合物,其中一半被鉴定为已知的纤维素热解产物。用甲醇、水或稀硝酸洗涤纸底物可显著减少热解产物和背景分子,其中水的改善效果最大。吗啡、芬太尼、甲基苯丙胺、伏立康唑和氟康唑洗涤后的信号没有减少,芬太尼和甲基苯丙胺洗涤后的信号明显增加,与切割方法无关。这项工作表明,虽然激光切割产生的热解产物会增加化学噪声,但论文中固有的背景分子也起着重要作用。简单的水洗可以缓解这两个问题,潜在地提高PS-MS对一系列分析物的整体性能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Identification and Mitigation of Pyrolysis Products in Laser-Cut Paper for Paper Spray Mass Spectrometry.

Paper spray mass spectrometry (PS-MS) often employs laser cutting to prepare paper substrates, potentially inducing localized thermal decomposition of the cellulose backbone. This work investigates how cellulose pyrolysis products and inherent background molecules within the paper affect PS-MS signal quality and evaluates paper pretreatment methods to enhance performance. Comparative analyses of laser-cut and razor-cut paper using mass spectrometry and ultraviolet-visible spectroscopy (UV-vis) showed significant differences. Laser-cut paper exhibited elevated MS blank signals and higher absorbance in the 200-400 nm UV region, indicating increased chemical abundance and complexity. Gas chromatography-mass spectrometry (GC-MS) identified over 20 residual compounds on laser-cut paper absent in razor-cut samples, half of which were identified as known cellulose pyrolysis products. Washing the paper substrates with methanol, water, or dilute nitric acid significantly reduced both pyrolysis products and background molecules, with water showing the most improvement. Analyses of morphine, fentanyl, methamphetamine, voriconazole, and fluconazole showed no reduction in the signal after washing, with fentanyl and methamphetamine exhibiting a significantly increased MS signal, regardless of the cutting method. This work reveals that while pyrolysis products from laser cutting contribute to increased chemical noise, inherent background molecules in the paper also play a significant role. A simple water wash mitigates both issues, potentially improving the overall PS-MS performance for a range of analytes.

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来源期刊
CiteScore
5.50
自引率
9.40%
发文量
257
审稿时长
1 months
期刊介绍: The Journal of the American Society for Mass Spectrometry presents research papers covering all aspects of mass spectrometry, incorporating coverage of fields of scientific inquiry in which mass spectrometry can play a role. Comprehensive in scope, the journal publishes papers on both fundamentals and applications of mass spectrometry. Fundamental subjects include instrumentation principles, design, and demonstration, structures and chemical properties of gas-phase ions, studies of thermodynamic properties, ion spectroscopy, chemical kinetics, mechanisms of ionization, theories of ion fragmentation, cluster ions, and potential energy surfaces. In addition to full papers, the journal offers Communications, Application Notes, and Accounts and Perspectives
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