低淀粉样蛋白-β PET保留额叶变异型阿尔茨海默病的诊断挑战。

IF 4.4 2区医学 Q1 CLINICAL NEUROLOGY

Annals of Clinical and Translational Neurology Pub Date : 2025-03-05 DOI:10.1002/acn3.70025

Ryosuke Shimasaki, Masanori Kurihara, Kenji Ishibashi, Aya Midori Tokumaru, Kenji Ishii, Atsushi Iwata

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引用次数: 0

摘要

诊断额叶变体阿尔茨海默病（fvAD）是困难的，当淀粉样蛋白- β (Aβ) PET保留率低时，可能会更加困难。一名63岁女性，有3年的冷漠和记忆障碍病史，MRI表现为执行功能障碍、记忆障碍和严重的双侧额颞叶萎缩。Aβ PET仅在右侧额叶显示模棱两可的结果，呈阴性。然而，脑脊液显示a β42/40比值严重降低，磷酸化-tau181升高。ad -tau特异性(18F)-MK6240 PET显示示踪剂潴留主要在双侧额叶增加，证实了fvAD的诊断。（18F）-MK6240 PET在解决低Aβ潴留的非典型患者的诊断不确定性方面有价值。

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Diagnostic Challenge in Frontal Variant Alzheimer's Disease With Low Amyloid-β PET Retention.

Diagnosing frontal variant Alzheimer's disease (fvAD) is difficult and could be even more difficult when amyloid-beta (Aβ) PET retention is low. A 63-year-old woman presenting with a 3-year history of apathy and memory impairment showed executive dysfunction, memory impairment, and severe bilateral frontotemporal atrophy on MRI. Aβ PET showed only equivocal findings in the right frontal lobe and was negative. However, CSF showed a severely decreased Aβ42/40 ratio and increased phospho-tau181. AD-tau-specific (18F)-MK6240 PET revealed increased tracer retention predominantly in the bilateral frontal lobes, confirming the fvAD diagnosis. (18F)-MK6240 PET can be valuable in resolving diagnostic uncertainties in atypical patients with low Aβ retention.

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来源期刊

Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)

CiteScore

9.10

自引率

1.90%

发文量

218

审稿时长

8 weeks

期刊介绍： Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.