{"title":"白藜芦醇载磺基丁醚β-环糊精和PVP k90基纳米纤维的静电纺丝制备及乳腺癌治疗","authors":"Priyanka Shinde, Amol Shete, Vishwajeet Ghorpade, Namdev Harale, Swapnali Patil, Namrata Desai, Snehal Patil","doi":"10.1007/s12247-025-09956-9","DOIUrl":null,"url":null,"abstract":"<div><h3>Purpose</h3><p>Breast cancer (BC) remains the leading cause of cancer-related mortality among women. This study aimed to improve the solubility, stability, and therapeutic efficacy of Resveratrol (RES) by developing an electrospun nanofiber mat for targeted drug delivery to breast tissue.</p><h3>Methods</h3><p>RES was incorporated into an inclusion complex with sulfobutylether β-cyclodextrin (SBE-β-Cyd) and polyvinylpyrrolidone (PVP K90). Polymer selection was guided by molecular docking and solution-state stability studies. The nanofibers were characterized using FTIR, DSC, XRD, and SEM, and evaluated for entrapment efficiency, moisture content, contact angle, and tensile strength. In vitro and ex vivo studies assessed drug release in phosphate buffer (pH 7.4) and biocompatibility using the HET-CAM assay. Antioxidant activity was analyzed via the DPPH assay, while anticancer potential was tested against MCF-7 breast cancer cells.</p><h3>Results</h3><p>The nanofibers demonstrated sustained RES release, enhanced solubility, and improved skin permeation. Biocompatibility studies confirmed their non-irritant nature and antioxidant assays showed maintained activity. Cytotoxicity assays indicated that RES-loaded nanofibers exhibited significant anticancer effects against MCF-7 cells, surpassing pure RES.</p><h3>Conclusion</h3><p>The developed RES-loaded nanofiber mat presents a promising localized treatment for breast cancer by overcoming RES’s solubility and stability limitations. The formulation enables sustained drug release and enhanced therapeutic efficacy, warranting further in vivo investigations to validate its clinical potential.</p></div>","PeriodicalId":656,"journal":{"name":"Journal of Pharmaceutical Innovation","volume":"20 2","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Formulation and Development of Resveratrol-Loaded Sulfobutylether β-Cyclodextrin and PVP K90-Based Nanofiber Mat Via Electrospinning for the Breast Cancer Therapy\",\"authors\":\"Priyanka Shinde, Amol Shete, Vishwajeet Ghorpade, Namdev Harale, Swapnali Patil, Namrata Desai, Snehal Patil\",\"doi\":\"10.1007/s12247-025-09956-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Purpose</h3><p>Breast cancer (BC) remains the leading cause of cancer-related mortality among women. This study aimed to improve the solubility, stability, and therapeutic efficacy of Resveratrol (RES) by developing an electrospun nanofiber mat for targeted drug delivery to breast tissue.</p><h3>Methods</h3><p>RES was incorporated into an inclusion complex with sulfobutylether β-cyclodextrin (SBE-β-Cyd) and polyvinylpyrrolidone (PVP K90). Polymer selection was guided by molecular docking and solution-state stability studies. The nanofibers were characterized using FTIR, DSC, XRD, and SEM, and evaluated for entrapment efficiency, moisture content, contact angle, and tensile strength. In vitro and ex vivo studies assessed drug release in phosphate buffer (pH 7.4) and biocompatibility using the HET-CAM assay. Antioxidant activity was analyzed via the DPPH assay, while anticancer potential was tested against MCF-7 breast cancer cells.</p><h3>Results</h3><p>The nanofibers demonstrated sustained RES release, enhanced solubility, and improved skin permeation. Biocompatibility studies confirmed their non-irritant nature and antioxidant assays showed maintained activity. Cytotoxicity assays indicated that RES-loaded nanofibers exhibited significant anticancer effects against MCF-7 cells, surpassing pure RES.</p><h3>Conclusion</h3><p>The developed RES-loaded nanofiber mat presents a promising localized treatment for breast cancer by overcoming RES’s solubility and stability limitations. The formulation enables sustained drug release and enhanced therapeutic efficacy, warranting further in vivo investigations to validate its clinical potential.</p></div>\",\"PeriodicalId\":656,\"journal\":{\"name\":\"Journal of Pharmaceutical Innovation\",\"volume\":\"20 2\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2025-03-06\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Pharmaceutical Innovation\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s12247-025-09956-9\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Pharmaceutical Innovation","FirstCategoryId":"3","ListUrlMain":"https://link.springer.com/article/10.1007/s12247-025-09956-9","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Formulation and Development of Resveratrol-Loaded Sulfobutylether β-Cyclodextrin and PVP K90-Based Nanofiber Mat Via Electrospinning for the Breast Cancer Therapy
Purpose
Breast cancer (BC) remains the leading cause of cancer-related mortality among women. This study aimed to improve the solubility, stability, and therapeutic efficacy of Resveratrol (RES) by developing an electrospun nanofiber mat for targeted drug delivery to breast tissue.
Methods
RES was incorporated into an inclusion complex with sulfobutylether β-cyclodextrin (SBE-β-Cyd) and polyvinylpyrrolidone (PVP K90). Polymer selection was guided by molecular docking and solution-state stability studies. The nanofibers were characterized using FTIR, DSC, XRD, and SEM, and evaluated for entrapment efficiency, moisture content, contact angle, and tensile strength. In vitro and ex vivo studies assessed drug release in phosphate buffer (pH 7.4) and biocompatibility using the HET-CAM assay. Antioxidant activity was analyzed via the DPPH assay, while anticancer potential was tested against MCF-7 breast cancer cells.
Results
The nanofibers demonstrated sustained RES release, enhanced solubility, and improved skin permeation. Biocompatibility studies confirmed their non-irritant nature and antioxidant assays showed maintained activity. Cytotoxicity assays indicated that RES-loaded nanofibers exhibited significant anticancer effects against MCF-7 cells, surpassing pure RES.
Conclusion
The developed RES-loaded nanofiber mat presents a promising localized treatment for breast cancer by overcoming RES’s solubility and stability limitations. The formulation enables sustained drug release and enhanced therapeutic efficacy, warranting further in vivo investigations to validate its clinical potential.
期刊介绍：
The Journal of Pharmaceutical Innovation (JPI), is an international, multidisciplinary peer-reviewed scientific journal dedicated to publishing high quality papers emphasizing innovative research and applied technologies within the pharmaceutical and biotechnology industries. JPI''s goal is to be the premier communication vehicle for the critical body of knowledge that is needed for scientific evolution and technical innovation, from R&D to market. Topics will fall under the following categories:
Materials science,
Product design,
Process design, optimization, automation and control,
Facilities; Information management,
Regulatory policy and strategy,
Supply chain developments ,
Education and professional development,
Journal of Pharmaceutical Innovation publishes four issues a year.
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