金催化烯烃1,2-羧基化反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-02-24 DOI:10.1021/acs.orglett.5c0028810.1021/acs.orglett.5c00288

Tanmayee Nanda, Avishek Das, Prafulla Bera and Nitin T. Patil*,

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引用次数: 0

摘要

在此，我们通过配体激活Au(I)/Au（III）催化揭示了一种前所未有的金催化的1,2-羧基化烯烃。不同于其他的C-C多键芳化功能化方法，利用弱亲核试剂如羧酸阴离子的尝试是不成功的。实现这一转变的关键是使用1,3-二酮附加的烯烃，该烯烃经过金催化的氧化芳基化，然后进行反醛醇反应以获得产品。为了支持提议的机制，进行了详细的机制调查。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Gold-Catalyzed 1,2-Carboxyarylation of Alkenes

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Gold-Catalyzed 1,2-Carboxyarylation of Alkenes

Herein, we disclose an unprecedented gold-catalyzed 1,2-carboxyarylation of alkenes through ligand-enabled Au(I)/Au(III) catalysis. Unlike other approaches for the arylative functionalization of C–C multiple bonds, attempts to utilize weak nucleophiles such as carboxylate anions were unsuccessful. The key to achieving this transformation is the use of a 1,3-diketone-appended alkene, which undergoes gold-catalyzed oxyarylation followed by retro-aldol reaction to afford the product. Detailed mechanistic investigations were conducted to support the proposed mechanism.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.