现在就一起来！ZCCHC3通过相凝聚协调胞质核酸传感

IF 14.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Cell Pub Date : 2025-03-06 DOI:10.1016/j.molcel.2025.02.009

Rebecca Barker, Eva Bartok

引用次数: 0

摘要

在本期Molecular Cell中，Shi等人1阐明了宿主因子ZCCHC3通过核酸结合和诱导液相冷凝，积极调节RLR和cGAS信号通路的新作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Come together, right now! ZCCHC3 orchestrates cytosolic nucleic acid sensing through phase condensation

In this issue of Molecular Cell, Shi et al.¹ elucidate a novel role of host factor ZCCHC3 in positively regulating RLR and cGAS signaling through the binding of nucleic acids and induction of liquid phase condensation.

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来源期刊

Molecular Cell 生物-生化与分子生物学

CiteScore

26.00

自引率

3.80%

发文量

389

审稿时长

1 months

期刊介绍： Molecular Cell is a companion to Cell, the leading journal of biology and the highest-impact journal in the world. Launched in December 1997 and published monthly. Molecular Cell is dedicated to publishing cutting-edge research in molecular biology, focusing on fundamental cellular processes. The journal encompasses a wide range of topics, including DNA replication, recombination, and repair; Chromatin biology and genome organization; Transcription; RNA processing and decay; Non-coding RNA function; Translation; Protein folding, modification, and quality control; Signal transduction pathways; Cell cycle and checkpoints; Cell death; Autophagy; Metabolism.