The Role of Acupuncture of 13 Ghost Points Combined with Cognitive Therapy in Alleviating Liver-qi Stagnation Depression: A Clinical Study.

Abstract: Liver-qi stagnation-type depression, marked by irritability and emotional imbalance, often responds inadequately to medication alone. This study explored the efficacy of combining acupuncture at the 13 ghost points with cognitive therapy for this condition. Conducted at our hospital from January 2022 to January 2023, the study involved 76 patients with liver-qi stagnation-type depression, divided into an observation group (acupuncture + cognitive therapy) and a control group (fluoxetine tablets), with 38 patients in each group. We assessed clinical efficacy, Hamilton Depression Scale (HAMD) scores, Self-Rating Depression Scale (SDS) scores, Traditional Chinese Medicine (TCM) syndrome scores, liver-qi stagnation syndrome main symptom scores, and serum levels of 5-hydroxytryptamine (HT), vasoactive intestinal peptide (VIP), and cAMP response element-binding protein (CREB) before and after treatment. The observation group achieved a total effective rate of 81.58%, significantly higher than the control group ( P < 0.05). Both groups showed significant reductions in HAMD and SDS scores, TCM syndrome scores, and liver-qi stagnation syndrome principal symptom scores posttreatment, with the observation group demonstrating superior improvements ( P < 0.05). Serum levels of 5-HT, VIP, and CREB also increased significantly in both groups, with greater changes in the observation group ( P < 0.05). The results suggest that the combination of acupuncture and cognitive therapy is more effective than fluoxetine alone in treating liver-qi stagnation-type depression, improving both clinical symptoms and physiological indicators.