T Mark Campbell, Robert Feibel, Jeffrey Dilworth, Odette Laneuville, Guy Trudel
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引用次数: 0
摘要
背景：骨关节炎（OA）与受影响关节的活动范围减小有关。有证据表明，这可能是由于后囊成纤维细胞的活性增加，而这些细胞又来自间充质基质细胞（MSCs）：目的：检验以下假设：(1) 膝关节屈曲挛缩（FC）患者后关节囊中间充质干细胞的数量更多，(2) 膝关节屈曲挛缩的 OA 患者后关节囊中间充质干细胞群向纤维化表型分化。为了实现这些目标，我们寻找了关节囊组织学和间充质干细胞结果与临床结果之间的关联：设计：横断面转化研究设计，使用来自渥太华膝骨关节炎（OKOA）数据库的数据：方法：共纳入 71 名 OKOA 数据库参与者及其相关临床和实验室结果。方法：共纳入 71 名 OKOA 数据库参与者及其相关临床和实验室结果：我们没有发现 FC 组和非 FC 组之间存在实验室差异。在后关节囊，膝关节屈曲与成脂能力（P = 0.001）、成骨能力（P = 0.039）、视觉模拟量表疼痛和纤维组织百分比（P = 0.014）之间存在关联。就前关节囊而言，膝关节屈曲（p = 0.002）和伸展（p = 0.005）与间充质干细胞计数有关，KL分级与间充质干细胞成纤维能力有关（p = 0.002），膝关节损伤和骨关节炎结果评分生活质量与软骨能力有关（p 结论：膝关节损伤和骨关节炎结果评分生活质量与间充质干细胞成纤维能力有关：关节囊成分、间充质干细胞计数和功能与重要的临床 OA 结果相关。这些研究结果表明，整个关节囊可能在与 OA 相关的发病率和进展中扮演着重要角色，并可能是一个未被重视的治疗 OA 的靶点。
Capsular stem cell function and tissue composition are associated with symptoms and radiographic severity in people with knee osteoarthritis.
Background: Osteoarthritis (OA) is associated with lost range of motion in the affected joint(s). Evidence suggests that this may be due to increased activity of posterior capsule fibroblasts, cells in turn derived from mesenchymal stromal cells (MSCs).
Objectives: To test the hypotheses that (1) MSCs are more numerous in the posterior capsule of patients with knee flexion contracture (FC) and (2) in OA participants with knee FC, the MSC population in the posterior capsule differentiates toward a fibrotic phenotype. In order to complete these objectives, we looked for associations between capsule histologic and MSC outcomes with clinical outcomes.
Design: Cross-sectional translational research design using data from the Ottawa Knee Osteoarthritis (OKOA) database.
Methods: A total of 71 OKOA database participants and their relevant clinical and laboratory outcomes were included. Associations were first tested with bivariate correlation, then for p < 0.10, tested using a linear model.
Results: No lab-based differences between FC and no-FC groups we discovered. In the posterior capsule, there was an association between knee flexion and adipogenic capacity (p = 0.001), osteogenic capacity (p < 0.001), KL grade and percent "other" (mainly neurovascular) tissue (p = 0.039), visual analog scale pain, and percent fibrous tissue (p = 0.014). For the anterior capsule, there was an association between knee flexion (p = 0.002) and extension (p = 0.005) with MSC enumeration, KL grade with MSC fibrogenic capacity (p = 0.002), and Knee Injury and Osteoarthritis Outcome Score quality of life with chondrogenic capacity (p < 0.001).
Conclusion: Joint capsule composition, MSC enumeration, and function were associated with important clinical OA outcomes. These findings suggest that the entire joint capsule may play an important role in OA-related morbidity and progression and could represent an underappreciated target for OA treatment.
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