V. K. Tishchenko, A. A. Pankratov, O. P. Vlasova, G. A. Demyashkin, A. V. Fedorova, E. A. Plotnikova, Yu. B. Venediktova, S. P. Orlenko, E. D. Stepchenkova, A. A. Ostroukhov, A. N. Shcherbakova, S. A. Ivanov, A. D. Kaprin
{"title":"放射性药物225Ac-DOTA-PSMA的一般毒性","authors":"V. K. Tishchenko, A. A. Pankratov, O. P. Vlasova, G. A. Demyashkin, A. V. Fedorova, E. A. Plotnikova, Yu. B. Venediktova, S. P. Orlenko, E. D. Stepchenkova, A. A. Ostroukhov, A. N. Shcherbakova, S. A. Ivanov, A. D. Kaprin","doi":"10.1134/S1063778824100508","DOIUrl":null,"url":null,"abstract":"<p>Radiopharmaceuticals (RPs) specific to prostate-specific membrane antigen (PSMA) are extremely promising for radioligand therapy of prostate cancer. The aim of this work was to study the general toxic properties of radiopharmaceutical <sup>225</sup>Ac-DOTA-PSMA after its single intravenous administration to laboratory animals (“acute” toxicity). It was shown that the administration of <sup>225</sup>Ac-DOTA-PSMA to mice and rats (males and females) in doses of 100, 200, and 500 kBq/kg was satisfactorily tolerated by the animals. No significant signs of intoxication or death of animals were observed. No pathomorphological changes in internal organs and tissues were detected at autopsy of animals. In mice treated with <sup>225</sup>Ac-DOTA-PSMA at doses of 200 and 500 kBq/kg, a decrease in the mass of salivary glands by 8–15% was observed compared to the control group (<i>p</i> > 0.05).</p>","PeriodicalId":728,"journal":{"name":"Physics of Atomic Nuclei","volume":"87 12","pages":"1923 - 1928"},"PeriodicalIF":0.3000,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"General Toxic Properties of the Radiopharmaceutical 225Ac-DOTA-PSMA\",\"authors\":\"V. K. Tishchenko, A. A. Pankratov, O. P. Vlasova, G. A. Demyashkin, A. V. Fedorova, E. A. Plotnikova, Yu. B. Venediktova, S. P. Orlenko, E. D. Stepchenkova, A. A. Ostroukhov, A. N. Shcherbakova, S. A. Ivanov, A. D. Kaprin\",\"doi\":\"10.1134/S1063778824100508\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Radiopharmaceuticals (RPs) specific to prostate-specific membrane antigen (PSMA) are extremely promising for radioligand therapy of prostate cancer. The aim of this work was to study the general toxic properties of radiopharmaceutical <sup>225</sup>Ac-DOTA-PSMA after its single intravenous administration to laboratory animals (“acute” toxicity). It was shown that the administration of <sup>225</sup>Ac-DOTA-PSMA to mice and rats (males and females) in doses of 100, 200, and 500 kBq/kg was satisfactorily tolerated by the animals. No significant signs of intoxication or death of animals were observed. No pathomorphological changes in internal organs and tissues were detected at autopsy of animals. In mice treated with <sup>225</sup>Ac-DOTA-PSMA at doses of 200 and 500 kBq/kg, a decrease in the mass of salivary glands by 8–15% was observed compared to the control group (<i>p</i> > 0.05).</p>\",\"PeriodicalId\":728,\"journal\":{\"name\":\"Physics of Atomic Nuclei\",\"volume\":\"87 12\",\"pages\":\"1923 - 1928\"},\"PeriodicalIF\":0.3000,\"publicationDate\":\"2025-03-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Physics of Atomic Nuclei\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1063778824100508\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSICS, NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics of Atomic Nuclei","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1134/S1063778824100508","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSICS, NUCLEAR","Score":null,"Total":0}
General Toxic Properties of the Radiopharmaceutical 225Ac-DOTA-PSMA
Radiopharmaceuticals (RPs) specific to prostate-specific membrane antigen (PSMA) are extremely promising for radioligand therapy of prostate cancer. The aim of this work was to study the general toxic properties of radiopharmaceutical 225Ac-DOTA-PSMA after its single intravenous administration to laboratory animals (“acute” toxicity). It was shown that the administration of 225Ac-DOTA-PSMA to mice and rats (males and females) in doses of 100, 200, and 500 kBq/kg was satisfactorily tolerated by the animals. No significant signs of intoxication or death of animals were observed. No pathomorphological changes in internal organs and tissues were detected at autopsy of animals. In mice treated with 225Ac-DOTA-PSMA at doses of 200 and 500 kBq/kg, a decrease in the mass of salivary glands by 8–15% was observed compared to the control group (p > 0.05).
期刊介绍：
Physics of Atomic Nuclei is a journal that covers experimental and theoretical studies of nuclear physics: nuclear structure, spectra, and properties; radiation, fission, and nuclear reactions induced by photons, leptons, hadrons, and nuclei; fundamental interactions and symmetries; hadrons (with light, strange, charm, and bottom quarks); particle collisions at high and superhigh energies; gauge and unified quantum field theories, quark models, supersymmetry and supergravity, astrophysics and cosmology.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
