α， β-不饱和羰基化合物可能参与了加热烟草制品烟气提取物诱导血管平滑肌细胞铁下垂

IF 3 3区医学 Q2 PHARMACOLOGY & PHARMACY

Journal of pharmacological sciences Pub Date : 2025-02-27 DOI:10.1016/j.jphs.2025.02.010

Takahiro Horinouchi , Yuichi Mazaki , Soichi Miwa

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引用次数: 0

摘要

在这项研究中，我们旨在确定血管平滑肌细胞中由加热烟草制品（HTPs）中无尼古丁和无焦油香烟烟雾提取物（CSE）诱导的铁下垂的细胞毒因子。CSE降低线粒体代谢活性，增加乳酸脱氢酶渗漏。从主流烟雾中去除羰基后，这些细胞毒性作用完全消失。HTPs和CSE的主流烟雾中的α、β-不饱和羰基化合物（丙烯醛、甲基乙烯酮、豆丁醛和甲基丙烯醛）可引起细胞损伤，这种损伤可被铁凋亡抑制剂UAMC-3203抑制。这些结果提示，α， β-不饱和羰基化合物可能参与了cse诱导的铁下垂。

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Possible involvement of α, β-unsaturated carbonyl compounds in ferroptosis induced by the cigarette smoke extract of heated tobacco products in vascular smooth muscle cells

In this study, we aimed to determine the cytotoxic factors involved in ferroptosis induced by nicotine- and tar-free cigarette smoke extract (CSE) from heated tobacco products (HTPs) in vascular smooth muscle cells. CSE decreased mitochondrial metabolic activity and increased lactate dehydrogenase leakage. These cytotoxic effects completely disappeared after removing the carbonyls from the mainstream smoke. α, β-Unsaturated carbonyl compounds (acrolein, methyl vinyl ketone, crotonaldehyde, and methacrolein) in the mainstream smoke of HTPs and CSE caused cell damage, which was inhibited by a ferroptosis inhibitor, UAMC-3203. These results suggest that α, β-unsaturated carbonyl compounds might be involved in CSE-induced ferroptosis.

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来源期刊

Journal of pharmacological sciences 医学-药学

CiteScore

6.20

自引率

2.90%

发文量

104

审稿时长

31 days

期刊介绍： Journal of Pharmacological Sciences (JPS) is an international open access journal intended for the advancement of pharmacological sciences in the world. The Journal welcomes submissions in all fields of experimental and clinical pharmacology, including neuroscience, and biochemical, cellular, and molecular pharmacology for publication as Reviews, Full Papers or Short Communications. Short Communications are short research article intended to provide novel and exciting pharmacological findings. Manuscripts concerning descriptive case reports, pharmacokinetic and pharmacodynamic studies without pharmacological mechanism and dose-response determinations are not acceptable and will be rejected without peer review. The ethnopharmacological studies are also out of the scope of this journal. Furthermore, JPS does not publish work on the actions of biological extracts unknown chemical composition.