Jose Rivera-Robles MD , Komal Alam MPH , Ahmed Abdelmonem MD , Audrene Edwards MS , Ahmad Abdelreheim MD , Susan K. Mathai MD , Michael Duncan MD , Chetan Naik MD, MS
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引用次数: 0
摘要
在世界卫生组织（WHO）第3组肺动脉高压（PH）患者中，热稀释法（TD）和间接菲克法（iFick）测量心输出量（CO）的比较尚未得到很好的描述。方法对96例WHO第3组PH行肺移植的患者进行单中心回顾性分析。作为比较，我们也将同期在我院PH诊所随访的32例WHO第1组肺动脉高压患者纳入研究。结果WHO 3组患者iFick CO与TD CO比较差异有统计学意义（5.93+/ -1.5 vs 5.46+/ -1.8 l /min, p=0.0061）， iFick与TD - CO计算肺血管阻力（PVR）也有统计学意义。TD-PVR与肺移植后不良预后指标的相关性更强。结论iFick- co与TD-CO在WHO 3组ph值有显著差异，iFick与TD-CO不一致时，TD-CO与肺移植术后临床预后的相关性更好。
Post lung-transplant predictive value of thermodilution vs estimated Fick cardiac output measurement
Background
Comparison of thermodilution (TD) and indirect Fick (iFick) methods of cardiac output (CO) measurement has not been well described in patients with World Health Organization (WHO) group 3 pulmonary hypertension (PH).
Methods
We conducted a single-center retrospective chart review of 96 patients with WHO group 3 PH who underwent lung transplantation. For comparison, 32 WHO group 1 pulmonary arterial hypertension patients who were followed in our PH clinic during the same period were also included in the study.
Results
TThere was a significant difference between iFick CO and TD CO (5.93+/ -1.5 versus 5.46+/ -1.8 liter/minute, p=0.0061) in WHO group 3 PH. Pulmonary vascular resistance (PVR) calculated using iFick and TD–CO values also differed significantly. TD–PVR was more strongly associated with measures of poor outcomes after lung transplant.
Conclusions
iFick-CO and TD-CO can be significantly different in WHO group 3 PH. In cases of discrepancy between iFick and TD-COs, TD-CO correlates better with clinical outcomes after lung transplantation.
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