铜介导的芳基/乙烯基硼酸的膦化反应

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-03-04 DOI:10.1021/acs.orglett.5c00444

Dongchang Han, Ao Wen, Ziheng Tian, Xiaowen Zhan, Chao Hu, Zhibin Luo, Peng Liu, Bin Liu

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引用次数: 0

摘要

继成功构建了硝基吡啶和磺胺盐之后，Chan-Lam偶联得到了显著的进展，首次展示了季磷盐的合成。我们提出了一种在三氟乙醇中使用醋酸铜（II）有效地从硼酸中生产一系列芳基和乙烯基磷盐的方法，包括从复杂的天然产物中提取的磷盐，从而克服了磷化氢氧化问题，并将范围扩大到功能化磷。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Copper-Mediated Phosphoniumation of Aryl/Vinyl Boronic Acids

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Copper-Mediated Phosphoniumation of Aryl/Vinyl Boronic Acids

Following the successful construction of nitrilium/pyridinium and sulfonium salts, the Chan–Lam coupling has been significantly advanced with the first demonstration of quaternary phosphonium salt synthesis. We present a method employing copper(II) acetate in trifluoroethanol to efficiently produce a range of aryl and vinyl phosphonium salts from boronic acids, including those derived from complex natural products, thus overcoming phosphine oxidation issues and expanding the scope to functionalized phosphorus.

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.