一次解码一个分子的亚细胞RNA定位

IF 10.1 1区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Genome Biology Pub Date : 2025-03-03 DOI:10.1186/s13059-025-03507-8

Josep Biayna, Gabrijela Dumbović

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引用次数: 0

摘要

真核细胞是高度结构化的，由多个膜结合和无膜细胞器组成。亚细胞RNA定位是RNA功能的关键调控因子，影响着各种生物过程。在任何给定的时刻，RNA必须精确地导航三维亚细胞环境，以确保适当的定位和功能，这受到许多因素的控制，包括剪接、RNA稳定性、修饰和定位序列。异常的RNA定位可以促进许多疾病的发展。在这里，我们探讨了不同的RNA定位机制，并总结了确定亚细胞RNA定位方法的进展，强调了成像技术改变了我们在单分子水平上研究RNA动力学的能力。

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Decoding subcellular RNA localization one molecule at a time

Eukaryotic cells are highly structured and composed of multiple membrane-bound and membraneless organelles. Subcellular RNA localization is a critical regulator of RNA function, influencing various biological processes. At any given moment, RNAs must accurately navigate the three-dimensional subcellular environment to ensure proper localization and function, governed by numerous factors, including splicing, RNA stability, modifications, and localizing sequences. Aberrant RNA localization can contribute to the development of numerous diseases. Here, we explore diverse RNA localization mechanisms and summarize advancements in methods for determining subcellular RNA localization, highlighting imaging techniques transforming our ability to study RNA dynamics at the single-molecule level.

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来源期刊

Genome Biology Biochemistry, Genetics and Molecular Biology-Genetics

CiteScore

21.00

自引率

3.30%

发文量

241

审稿时长

2 months

期刊介绍： Genome Biology stands as a premier platform for exceptional research across all domains of biology and biomedicine, explored through a genomic and post-genomic lens. With an impressive impact factor of 12.3 (2022),* the journal secures its position as the 3rd-ranked research journal in the Genetics and Heredity category and the 2nd-ranked research journal in the Biotechnology and Applied Microbiology category by Thomson Reuters. Notably, Genome Biology holds the distinction of being the highest-ranked open-access journal in this category. Our dedicated team of highly trained in-house Editors collaborates closely with our esteemed Editorial Board of international experts, ensuring the journal remains on the forefront of scientific advances and community standards. Regular engagement with researchers at conferences and institute visits underscores our commitment to staying abreast of the latest developments in the field.