主动脉分支保留策略对B型主动脉夹层血栓生长预测的影响:一项血流动力学研究

IF 4.9 2区 医学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS
Jun Wen , Qingyuan Huang , Xiaoqin Chen , Kaiyue Zhang , Liqing Peng
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引用次数: 0

摘要

背景:B型主动脉夹层(TBAD)是一种严重的心血管疾病,TEVAR(胸椎血管内主动脉修复术)可以有效治疗,它以最小的侵入性促进假腔血栓形成。然而,主动脉分支保留策略对血栓生长预测的影响往往被低估。方法对四种分支保留策略进行数值研究:保留所有分支(1型策略)、切除所有分支(2型策略)、仅切除主动脉弓分支(3型策略)和仅切除腹主动脉分支(4型策略)。结果4型策略具有与1型相似的血流动力学稳定性、剪应力分布和血栓形成风险,同时简化了解剖结构。相反,完全切除分支(2型)和仅保留主动脉弓分支(3型)会导致明显的血流紊乱和血流动力学不稳定,潜在地增加假腔扩张和血栓误判的风险。此外,通过减少图像分割和3D重建的工作量,同时提高模型训练的效率和准确性,Type 4策略在图像简化和深度学习应用中显示出潜在的价值。本研究建议在主动脉图像简化和TEVAR手术计划中优先考虑4型策略,以保持血流动力学稳定性,同时降低计算复杂性。这种方法对个性化治疗和基于深度学习的分析都有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Impact of aortic branch retention strategies on thrombus growth prediction in type B aortic dissection: A hemodynamic study

Background

Type B Aortic Dissection (TBAD) is a serious cardiovascular condition treated effectively by TEVAR (Thoracic Endovascular Aortic Repair), which promotes false lumen thrombosis with minimal invasiveness. However, the impact of aortic branch retention strategies on thrombus growth prediction is often underestimated.

Method

This study numerically investigated four branch retention strategies: preserving all branches (Type 1 strategy), removing all branches (Type 2 strategy), removing only the aortic arch branches (Type 3 strategy), and removing only the abdominal aortic branches (Type 4 strategy).

Results

Type 4 strategy demonstrates similar hemodynamic stability, shear stress distribution, and thrombus formation risk as Type 1, while simplifying the anatomical structure. In contrast, complete branch removal (Type 2) and retention of only the aortic arch branches (Type 3) lead to significant flow disturbances and hemodynamic instability, potentially increasing the risk of false lumen expansion and thrombus misjudgment. Additionally, Type 4 strategy shows potential value in image simplification and deep learning applications by reducing the workload of image segmentation and 3D reconstruction while improving model training efficiency and accuracy.

Conclusion

This study recommends prioritizing the Type 4 strategy in aortic image simplification and TEVAR surgical planning to maintain hemodynamic stability while reducing computational complexity. This approach has significant implications for both personalized treatment and deep learning-based analyses.
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来源期刊
Computer methods and programs in biomedicine
Computer methods and programs in biomedicine 工程技术-工程:生物医学
CiteScore
12.30
自引率
6.60%
发文量
601
审稿时长
135 days
期刊介绍: To encourage the development of formal computing methods, and their application in biomedical research and medical practice, by illustration of fundamental principles in biomedical informatics research; to stimulate basic research into application software design; to report the state of research of biomedical information processing projects; to report new computer methodologies applied in biomedical areas; the eventual distribution of demonstrable software to avoid duplication of effort; to provide a forum for discussion and improvement of existing software; to optimize contact between national organizations and regional user groups by promoting an international exchange of information on formal methods, standards and software in biomedicine. Computer Methods and Programs in Biomedicine covers computing methodology and software systems derived from computing science for implementation in all aspects of biomedical research and medical practice. It is designed to serve: biochemists; biologists; geneticists; immunologists; neuroscientists; pharmacologists; toxicologists; clinicians; epidemiologists; psychiatrists; psychologists; cardiologists; chemists; (radio)physicists; computer scientists; programmers and systems analysts; biomedical, clinical, electrical and other engineers; teachers of medical informatics and users of educational software.
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