声光化学方法在负载酞菁铟的半胱氨酸功能化石墨烯量子点上的应用

IF 2.4 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Polyhedron Pub Date : 2025-02-28 DOI:10.1016/j.poly.2025.117468

Gökçe Gökçil , Kevser Celep , Pınar Şen , Fikrettin Şahin , Ali Erdoğmuş , Göknur Yaşa Atmaca

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引用次数: 0

摘要

现有的光动力治疗（PDT）药物面临单线态产氧量低、严重的光漂白和生物相容性差等挑战。为了克服这些问题，我们提出了一种将新合成的酞菁与半胱氨酸功能化石墨烯量子点（cys-GQDs）结合的新方法。这种方法旨在提高单线态氧的产生、溶解度和在生物环境中的稳定性。本研究合成了一种新的酞菁铟及其cys-GQDs （InPc@cys-GQDs）衍生物，作为一种新的超声光敏剂用于治疗。评估了它们的光化学和声光化学性质，重点是单线态产氧效率。此外，通过体外实验测试了这些药物的稳定性、光稳定性、细胞摄取和生物相容性。结果表明，InPc@cys-GQDs共轭物的单重态氧产率明显高于单纯的酞菁试剂，尤其是声光动力法。它们还表现出改善的细胞内化和降低的细胞毒性，这表明它们为临床PDT应用提供了有希望的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Application of sono-photochemical methods to cysteine-functionalized graphene quantum dots loaded with indium phthalocyanine for enhanced singlet oxygen generation

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Application of sono-photochemical methods to cysteine-functionalized graphene quantum dots loaded with indium phthalocyanine for enhanced singlet oxygen generation

Existing photodynamic therapy (PDT) agents face challenges such as low singlet oxygen production, severe photobleaching, and poor biocompatibility. To overcome these issues, we propose a novel method combining newly synthesized phthalocyanine with cysteine-functionalized graphene quantum dots (cys-GQDs). This approach aims to enhance singlet oxygen production, solubility and stability in biological environments.

In this study a new indium phthalocyanine and its cys-GQDs (InPc@cys-GQDs) derivative were synthesized as a new sono-photosensitizer candidate for therapeutic applications. Their photochemical and sono-photochemical properties were evaluated, focusing on singlet oxygen generation efficiency. Additionally, the stability, photostability, cellular uptake, and biocompatibility of these agents were tested through in vitro assays. The results show that the InPc@cys-GQDs conjugate has significantly higher singlet oxygen yield, especially with sono-photodynamic method compared to only phthalocyanine agent. They also demonstrate improved cellular internalization and reduced cytotoxicity, suggesting they offer a promising advancement for clinical PDT applications.

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来源期刊

Polyhedron 化学-晶体学

CiteScore

4.90

自引率

7.70%

发文量

515

审稿时长

2 months

期刊介绍： Polyhedron publishes original, fundamental, experimental and theoretical work of the highest quality in all the major areas of inorganic chemistry. This includes synthetic chemistry, coordination chemistry, organometallic chemistry, bioinorganic chemistry, and solid-state and materials chemistry. Papers should be significant pieces of work, and all new compounds must be appropriately characterized. The inclusion of single-crystal X-ray structural data is strongly encouraged, but papers reporting only the X-ray structure determination of a single compound will usually not be considered. Papers on solid-state or materials chemistry will be expected to have a significant molecular chemistry component (such as the synthesis and characterization of the molecular precursors and/or a systematic study of the use of different precursors or reaction conditions) or demonstrate a cutting-edge application (for example inorganic materials for energy applications). Papers dealing only with stability constants are not considered.