氧化应激和炎症对欧洲糖尿病前期受试者代谢异常和肾脏受累的影响

IF 2 4区 医学 Q2 UROLOGY & NEPHROLOGY
Sebastián Mas-Fontao , Esther Civantos , Nisa Boukichou-Abdelkader , Manuel Soto-Catalan , Marta Romeo-Colas , Arantxa Marco , Carmen Gomez-Guerrero , Juan Antonio Moreno , Jaakko Tuomilehto , Rafael Gabriel , Jesús Egido , on behalf of ePREDICE investigators
{"title":"氧化应激和炎症对欧洲糖尿病前期受试者代谢异常和肾脏受累的影响","authors":"Sebastián Mas-Fontao ,&nbsp;Esther Civantos ,&nbsp;Nisa Boukichou-Abdelkader ,&nbsp;Manuel Soto-Catalan ,&nbsp;Marta Romeo-Colas ,&nbsp;Arantxa Marco ,&nbsp;Carmen Gomez-Guerrero ,&nbsp;Juan Antonio Moreno ,&nbsp;Jaakko Tuomilehto ,&nbsp;Rafael Gabriel ,&nbsp;Jesús Egido ,&nbsp;on behalf of ePREDICE investigators","doi":"10.1016/j.nefro.2024.10.003","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Studying the mechanisms involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associated with oxidative stress and inflammation in prediabetic individuals across Europe.</div></div><div><h3>Methods</h3><div>In plasma samples from individuals with prediabetes included in the ePREDICE study, we determined molecules related to oxidative stress (advance oxidative protein products-AOPP) and inflammatory biomarkers (C-reactive protein – CRP; Interleukin 6 – IL-6), and correlated them with anthropometric and biochemical data, assessing their potential for the early diagnosis of renal involvement.</div></div><div><h3>Results</h3><div>Among the 967 people with prediabetes, 94 presented some sign of renal impairment such as albuminuria, hyperfiltration or hypofiltration. Significant variations were identified between oxidative stress and inflammatory biomarkers (upper and lower quartiles of AOPP, CRP and IL6), and parameters associated with blood pressure, glucose metabolism, lipid profile, and fatty liver index. In particular, both types of biomarkers were associated with components of the metabolic syndrome. There were significant associations between AOPP and CRP, and the presence of albuminuria, but not with renal function. Overall, CRP was a better biomarker than IL-6 for most of the parameters studied.</div></div><div><h3>Conclusion</h3><div>These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results need to be confirmed, our study suggests that AOPP and CRP could be simple biomarkers of interest in predicting the risk of loss of renal function in people with prediabetes.</div></div>","PeriodicalId":18997,"journal":{"name":"Nefrologia","volume":"45 3","pages":"Pages 238-248"},"PeriodicalIF":2.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe\",\"authors\":\"Sebastián Mas-Fontao ,&nbsp;Esther Civantos ,&nbsp;Nisa Boukichou-Abdelkader ,&nbsp;Manuel Soto-Catalan ,&nbsp;Marta Romeo-Colas ,&nbsp;Arantxa Marco ,&nbsp;Carmen Gomez-Guerrero ,&nbsp;Juan Antonio Moreno ,&nbsp;Jaakko Tuomilehto ,&nbsp;Rafael Gabriel ,&nbsp;Jesús Egido ,&nbsp;on behalf of ePREDICE investigators\",\"doi\":\"10.1016/j.nefro.2024.10.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Studying the mechanisms involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associated with oxidative stress and inflammation in prediabetic individuals across Europe.</div></div><div><h3>Methods</h3><div>In plasma samples from individuals with prediabetes included in the ePREDICE study, we determined molecules related to oxidative stress (advance oxidative protein products-AOPP) and inflammatory biomarkers (C-reactive protein – CRP; Interleukin 6 – IL-6), and correlated them with anthropometric and biochemical data, assessing their potential for the early diagnosis of renal involvement.</div></div><div><h3>Results</h3><div>Among the 967 people with prediabetes, 94 presented some sign of renal impairment such as albuminuria, hyperfiltration or hypofiltration. Significant variations were identified between oxidative stress and inflammatory biomarkers (upper and lower quartiles of AOPP, CRP and IL6), and parameters associated with blood pressure, glucose metabolism, lipid profile, and fatty liver index. In particular, both types of biomarkers were associated with components of the metabolic syndrome. There were significant associations between AOPP and CRP, and the presence of albuminuria, but not with renal function. Overall, CRP was a better biomarker than IL-6 for most of the parameters studied.</div></div><div><h3>Conclusion</h3><div>These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results need to be confirmed, our study suggests that AOPP and CRP could be simple biomarkers of interest in predicting the risk of loss of renal function in people with prediabetes.</div></div>\",\"PeriodicalId\":18997,\"journal\":{\"name\":\"Nefrologia\",\"volume\":\"45 3\",\"pages\":\"Pages 238-248\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nefrologia\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0211699524000973\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"UROLOGY & NEPHROLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nefrologia","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0211699524000973","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}
引用次数: 0

摘要

研究前驱糖尿病向糖尿病及其相关并发症(如肾脏疾病)转变的机制是一个越来越大的挑战。这项研究的重点是确定早期检测肾损伤的有价值的生物标志物,评估欧洲糖尿病前期个体中与氧化应激和炎症相关的分子。方法在ePREDICE研究中纳入的糖尿病前期患者的血浆样本中,我们检测了与氧化应激相关的分子(高级氧化蛋白产物- aopp)和炎症生物标志物(c -反应蛋白- CRP;白细胞介素6 - IL-6),并将其与人体测量和生化数据相关联,评估其早期诊断肾脏受累的潜力。结果967例糖尿病前期患者中,94例出现蛋白尿、高滤过或低滤过等肾损害征象。氧化应激和炎症生物标志物(AOPP、CRP和IL6的上下四分位数)以及与血压、葡萄糖代谢、脂质谱和脂肪肝指数相关的参数之间存在显著差异。特别是,这两种类型的生物标志物都与代谢综合征的组成部分有关。AOPP和CRP与蛋白尿存在有显著相关性,但与肾功能无显著相关性。总的来说,在研究的大多数参数中,CRP是比IL-6更好的生物标志物。结论这些结果强调了氧化应激和炎症与糖尿病前期代谢异常及其并发症(如脂肪肝和肾脏受累)的重要关联。虽然这些结果还有待证实,但我们的研究表明,AOPP和CRP可能是预测糖尿病前期患者肾功能丧失风险的简单生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative stress and inflammation on metabolic abnormalities and renal involvement in prediabetic subjects across Europe

Background

Studying the mechanisms involved in the transition from prediabetes to diabetes and its associated complications, such as kidney disease, is a growing challenge. This study focuses on identifying valuable biomarkers for the early detection of kidney damage, evaluating molecules associated with oxidative stress and inflammation in prediabetic individuals across Europe.

Methods

In plasma samples from individuals with prediabetes included in the ePREDICE study, we determined molecules related to oxidative stress (advance oxidative protein products-AOPP) and inflammatory biomarkers (C-reactive protein – CRP; Interleukin 6 – IL-6), and correlated them with anthropometric and biochemical data, assessing their potential for the early diagnosis of renal involvement.

Results

Among the 967 people with prediabetes, 94 presented some sign of renal impairment such as albuminuria, hyperfiltration or hypofiltration. Significant variations were identified between oxidative stress and inflammatory biomarkers (upper and lower quartiles of AOPP, CRP and IL6), and parameters associated with blood pressure, glucose metabolism, lipid profile, and fatty liver index. In particular, both types of biomarkers were associated with components of the metabolic syndrome. There were significant associations between AOPP and CRP, and the presence of albuminuria, but not with renal function. Overall, CRP was a better biomarker than IL-6 for most of the parameters studied.

Conclusion

These results highlight the important associations of oxidative stress and inflammation with metabolic abnormalities linked to the prediabetic state and its complications such as fatty liver and renal involvement. Although these results need to be confirmed, our study suggests that AOPP and CRP could be simple biomarkers of interest in predicting the risk of loss of renal function in people with prediabetes.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Nefrologia
Nefrologia 医学-泌尿学与肾脏学
CiteScore
3.40
自引率
7.70%
发文量
148
审稿时长
47 days
期刊介绍: Nefrología is the official publication of the Spanish Society of Nephrology. The Journal publishes articles on basic or clinical research relating to nephrology, arterial hypertension, dialysis and kidney transplants. It is governed by the peer review system and all original papers are subject to internal assessment and external reviews. The journal accepts submissions of articles in English and in Spanish languages.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信