氧化应激与小儿糖尿病心血管并发症:新兴研究与临床应用。

IF 4.1 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Saman Saedi, Yi Tan, Sara E Watson, Joshua D Sparks, Kupper A Wintergerst, Lu Cai
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引用次数: 0

摘要

在过去的三十年中,儿科糖尿病的患病率和发病率急剧增加。相比之下,与成人糖尿病相比,儿童糖尿病有更快的胰腺β细胞衰退和早期并发症进展。因此,糖尿病并发症是儿童和青少年糖尿病患者的主要关注点。糖尿病对宏观和微血管系统有不利影响,导致心血管疾病,这是青年糖尿病患者发病和死亡的主要原因。氧化应激在儿童糖尿病心血管并发症的发生中起关键作用。在患有糖尿病的儿科患者中,有几个因素可能导致活性氧过剩和氧化应激的发生,包括营养缺乏、青春期、环境暴露和代谢紊乱,如肥胖和高血压。本研究旨在提高对儿童和青少年糖尿病心血管并发症的认识,以及氧化应激在心血管并发症发病中的作用及其分子机制。此外,还强调了一些治疗和预防儿科糖尿病心血管并发症的新治疗策略。综上所述,儿童和青少年糖尿病无论是T1D还是T2D,都有许多与成人同类糖尿病相似的特征,但也有许多不同于成人的特征。通过开发有针对性的治疗和预防措施,医疗保健提供者可以更好地解决儿童和青少年中糖尿病相关并发症发病率上升的问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Oxidative stress and pediatric diabetic cardiovascular complications: emerging research and clinical applications.

The prevalence and incidence of diabetes in pediatrics have dramatically increased over the last three decades. Comparatively, pediatric diabetes has faster pancreatic β-cells decline and early progression to complications compared with adult diabetes. Therefore, diabetic complications are a major concern in children and adolescents with diabetes. Diabetes has detrimental effects on the macro- and microvascular systems, resulting in cardiovascular diseases, leading causes of morbidity and mortality in youth with diabetes. Oxidative stress plays a critical role in developing cardiovascular complications in the context of pediatric diabetes. In pediatric patients with diabetes, several factors can contribute to the development of excess reactive oxygen species and oxidative stress, including nutritional deficiencies, puberty, environmental exposures, and metabolic disorders such as obesity and high blood pressure. The present study aims to raise awareness of diabetic cardiovascular complications in children and adolescents with diabetes and the role of oxidative stress and their molecular mechanisms in the pathogenesis of cardiovascular complications. In addition, some novel therapeutic strategies for the treatment and prevention of diabetic cardiovascular complications in the pediatric populations are highlighted. In summary, children and adolescents with diabetes no matter type 1 diabetes (T1D) or type 1 diabetes (T2D), have many features similar to those in adults with same kinds of diabetes, but also have many their own features distinct from adults. By developing targeted therapies and preventive measures, healthcare providers can better address the rising incidence of diabetes-related complications in children and adolescents.

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来源期刊
CiteScore
9.60
自引率
10.40%
发文量
202
审稿时长
2-4 weeks
期刊介绍: The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact and integrative animal and organ function to the cellular, subcellular, and molecular levels. The journal embraces new descriptions of these functions and their control systems, as well as their basis in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new mechanistic physiological insights that determine the performance of the normal and abnormal heart and circulation.
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