非编码 RNA 作为挽救心血管疾病线粒体功能障碍的潜在疗法

IF 4.1 2区 医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS
Hafsat O Alabere, Andrew D Taylor, Brianna R Miller, Remi Nohoesu, Roxy Nicoletti, Joshua Mogus, Ethan M Meadows, John M Hollander
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引用次数: 0

摘要

非编码rna (ncRNAs)是心血管疾病中线粒体功能的关键调节因子。一些研究已经探索了不同心血管疾病背景下ncRNAs在线粒体功能障碍中的操纵,然而,关于这些非编码rna作为改善心血管疾病的实际治疗方法的探索信息缺乏。本系统综述探讨了各种ncrna在主要心血管疾病中调节线粒体功能障碍中的作用,以及它们如何靶向线粒体。根据PRISMA指南,使用Web of Science和Scopus数据库进行了全面的文献检索。关注特定心血管疾病中ncrna和线粒体功能障碍的英文原创研究文章符合入选条件。该系统综述共纳入了76项研究,其中多达100个ncrna被确定为治疗性生物标志物。鉴定的ncrna参与调节线粒体过程,包括氧化磷酸化、裂变/融合动力学、细胞凋亡和心血管疾病中的钙处理。线粒体靶向部分,包括线粒体靶向细胞穿透肽、线粒体靶向脂质体和适配体,可以与ncrna结合,并通过心包或心肌等多种注射途径递送到心脏。然而,在体内开发有效的递送方法来调节这些ncrna仍然存在重大挑战。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Noncoding RNA as potential therapeutics to rescue mitochondrial dysfunction in cardiovascular diseases.

Noncoding RNAs (ncRNAs) are critical regulators of mitochondrial function in cardiovascular diseases. Several studies have explored the manipulation of ncRNAs in mitochondrial dysfunction in different cardiovascular disease contexts, however, there is a dearth of information on the exploration of these noncoding RNAs as actual therapeutics to ameliorate cardiovascular diseases. This systematic review examines the roles of various ncRNAs in modulating mitochondrial dysfunction across major cardiovascular diseases and how they can be targeted to the mitochondria. A comprehensive literature search was conducted using Web of Science and Scopus databases, following the PRISMA guidelines. Original research articles in the English language, focusing on ncRNAs and mitochondrial dysfunction in specific cardiovascular diseases, were eligible for inclusion. A total of 76 studies were included in the systematic review with up to 100 ncRNAs identified as therapeutic biomarkers. The identified ncRNAs participate in regulating mitochondrial processes including oxidative phosphorylation (OXPHOS), fission/fusion dynamics, apoptosis, and calcium handling in cardiovascular diseases. Mitochondrial targeting moieties including mitochondrial targeting cell-penetrating peptides, mitochondrial targeting liposomes, and aptamers can be conjugated to ncRNAs and delivered to the heart via various injection routes including the pericardium or the myocardium. However, significant challenges remain in developing effective delivery methods to modulate these ncRNAs in vivo.

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来源期刊
CiteScore
9.60
自引率
10.40%
发文量
202
审稿时长
2-4 weeks
期刊介绍: The American Journal of Physiology-Heart and Circulatory Physiology publishes original investigations, reviews and perspectives on the physiology of the heart, vasculature, and lymphatics. These articles include experimental and theoretical studies of cardiovascular function at all levels of organization ranging from the intact and integrative animal and organ function to the cellular, subcellular, and molecular levels. The journal embraces new descriptions of these functions and their control systems, as well as their basis in biochemistry, biophysics, genetics, and cell biology. Preference is given to research that provides significant new mechanistic physiological insights that determine the performance of the normal and abnormal heart and circulation.
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