用于转移性肿瘤生长生物观测值数值计算的新型 MATLAB 软件

IF 4.4 2区数学 Q1 COMPUTER SCIENCE, INTERDISCIPLINARY APPLICATIONS

Mathematics and Computers in Simulation Pub Date : 2025-02-19 DOI:10.1016/j.matcom.2025.02.014

Iulia Martina Bulai , Maria Carmela De Bonis , Concetta Laurita

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A new MATLAB software for numerical computation of biological observables for metastatic tumor growth

In this paper a new MATLAB Toolbox is introduced, Metastatic Tumor Growth Modeling (MTGM). MTGM Toolbox is freely available on a GitHub repository https://github.com/IuliaMartinaBulai/MTGM_Toolbox and equips the researchers with five different functionalities. The first one refers to the numerical resolution of a general Volterra Integral Equation (VIE) of the second kind on the positive semiaxis while the last four ones to the computation of biological observables related to metastatic tumor growth models. In particular, the computed observables are the cumulative number of metastases (CNM) and the total metastatic mass (TMM) derived from: (i) a 1D metastatic tumor growth (t.g.) model where the analytical solution of the ODE describing the t.g. law is known, (ii) a 1D model where this solution has to be numerically computed, (iii) a 2D non-autonomous metastatic t.g. model where also the treatment is considered, (iv) a 2D autonomous model, i.e., in the absence of therapies. Moreover, the Toolbox implementation was designed in order to give the users the possibility to extend its functionalities.

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来源期刊

Mathematics and Computers in Simulation 数学-计算机：跨学科应用

CiteScore

8.90

自引率

4.30%

发文量

335

审稿时长

54 days

期刊介绍： The aim of the journal is to provide an international forum for the dissemination of up-to-date information in the fields of the mathematics and computers, in particular (but not exclusively) as they apply to the dynamics of systems, their simulation and scientific computation in general. Published material ranges from short, concise research papers to more general tutorial articles. Mathematics and Computers in Simulation, published monthly, is the official organ of IMACS, the International Association for Mathematics and Computers in Simulation (Formerly AICA). This Association, founded in 1955 and legally incorporated in 1956 is a member of FIACC (the Five International Associations Coordinating Committee), together with IFIP, IFAV, IFORS and IMEKO. Topics covered by the journal include mathematical tools in: •The foundations of systems modelling •Numerical analysis and the development of algorithms for simulation They also include considerations about computer hardware for simulation and about special software and compilers. The journal also publishes articles concerned with specific applications of modelling and simulation in science and engineering, with relevant applied mathematics, the general philosophy of systems simulation, and their impact on disciplinary and interdisciplinary research. The journal includes a Book Review section -- and a "News on IMACS" section that contains a Calendar of future Conferences/Events and other information about the Association.