常见脊柱肿瘤中的MicroRNA异常及其靶基因

IF 1.4 4区 医学 Q4 GENETICS & HEREDITY
Razieh Tavakoli Oliaee , Majid Reza Farrokhi , Hamid Moeeni , Rahele Tavakoly , Morteza Jafarinia , Farideh Iravanpour
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引用次数: 0

摘要

脊柱肿瘤虽然罕见,但由于其复杂的生物学行为和肿瘤类型的多样性,在诊断和治疗方面提出了重大挑战。MicroRNAs (miRNAs)是一种小的非编码RNA分子,已成为基因表达的关键调节因子,并根据其靶基因发挥癌基因或肿瘤抑制因子的双重作用。本文基于现有的人类和体外模型研究,全面探讨了mirna在常见脊柱肿瘤(包括室管膜瘤、星形细胞瘤、脑膜瘤和转移)的发病和进展中的作用。一些mirna在这些肿瘤类型中被鉴定为失调,影响关键的细胞过程,如增殖、迁移和凋亡。mirna作为诊断、预后和治疗生物标志物的潜力被探索,突出了它们在指导个性化治疗方法方面的价值。虽然这些发现很有希望,但需要进一步验证以充分了解mirna介导的机制并将这些见解转化为临床应用。mirna靶向治疗为改善脊柱肿瘤治疗患者的预后提供了一条有希望的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
MicroRNA dysregulation and target genes in common spinal tumors
Spinal tumors, although rare, pose significant challenges in diagnosis and treatment due to their complex biological behavior and the variety of tumor types involved. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as critical regulators of gene expression and play dual roles as oncogenes or tumor suppressors, depending on their target genes. This review comprehensively examines the role of miRNAs in the pathogenesis and progression of common spinal tumors, including ependymoma, astrocytoma, meningioma, and metastasis, based on existing studies using both human and in vitro models. Several miRNAs have been identified as dysregulated in these tumor types, influencing key cellular processes such as proliferation, migration, and apoptosis. The potential of miRNAs as diagnostic, prognostic, and therapeutic biomarkers is explored, highlighting their value in guiding personalized treatment approaches. Although promising, these findings require further validation to fully understand miRNA-mediated mechanisms and translate these insights into clinical applications. MiRNA-targeted therapies offer a promising avenue for improving patient outcomes in spinal tumor management.
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来源期刊
Cancer Genetics
Cancer Genetics ONCOLOGY-GENETICS & HEREDITY
CiteScore
3.20
自引率
5.30%
发文量
167
审稿时长
27 days
期刊介绍: The aim of Cancer Genetics is to publish high quality scientific papers on the cellular, genetic and molecular aspects of cancer, including cancer predisposition and clinical diagnostic applications. Specific areas of interest include descriptions of new chromosomal, molecular or epigenetic alterations in benign and malignant diseases; novel laboratory approaches for identification and characterization of chromosomal rearrangements or genomic alterations in cancer cells; correlation of genetic changes with pathology and clinical presentation; and the molecular genetics of cancer predisposition. To reach a basic science and clinical multidisciplinary audience, we welcome original full-length articles, reviews, meeting summaries, brief reports, and letters to the editor.
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