前列腺癌患者血浆IL-1β浓度与睡眠质量和认知功能相关

IF 2.3 4区 医学 Q1 NURSING
Mayra Alejandra Mafla-España RN, PhD , Elsa Vitale RN, PhD , María Dolores Torregrosa MD, PhD , Omar Cauli MD, PhD
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引用次数: 0

摘要

目的:本研究的目的是确定前列腺癌(PCa)患者在雄激素剥夺治疗(ADT)期间睡眠质量是否改变,睡眠障碍是否与抑郁症状、认知功能或虚弱综合征相关,以及局限性或转移性疾病患者之间是否存在差异。促炎细胞因子IL-1β参与睡眠调节,我们评估了IL-1β浓度是否与睡眠质量、抑郁症状、认知功能或虚弱综合征相关。方法:使用雅典失眠量表(AIS)评估睡眠质量,使用Yesavage量表(GDS)评估抑郁症状,使用最小状态检查(MMSE)评估认知功能,并根据Fried标准测量虚弱程度。采用酶联免疫分析法测定血浆IL-1β。采用线性回归分析来确定哪些变量预测血浆IL-1β与睡眠质量差和IL-1β浓度升高有关。结果:在2021年至2023年期间进行了横断面研究。67名前列腺癌男性患者(N=36(53.7%)伴有局限性疾病,N=31(46.3%)伴有转移性疾病)纳入研究。血浆IL-1β浓度与所有样本中较差的睡眠质量相关,并且转移性前列腺癌患者的睡眠质量比局限性前列腺癌患者差。自我报告的睡眠质量分析显示,一半的人有失眠症状,19.4%的人报告有临床相关的失眠障碍(AIS平均值3.39±0.44)。睡眠质量差显著预测血浆中IL-1β的浓度。相比之下,较好的认知功能显著预测IL-1β浓度(P = .037)。对AIS项目的详细分析表明,“睡眠诱导”和“da期间嗜睡”项目的得分显著预测IL-1β浓度(P = )。001和P0=。044年,分别)。结论:血浆IL-1β水平可能有助于解决接受ADT治疗的PCa患者的失眠问题,并监测干预措施改善这些患者睡眠问题的效果。对护理实践的启示:护士将在教育患者基于特定生物标志物(如IL-1β和睡眠质量)的特定症状风险方面发挥关键作用。护士将参与使用生物标志物数据来滴定药物,并评估非药物干预措施对改善PCa患者睡眠质量的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Plasma IL-1β Concentration Associates with Sleep Quality and Cognitive Functions in Men with Prostate Cancer

Objectives

The purpose of this study was to ascertain whether sleep quality is altered in patients with prostate cancer (PCa) during androgen deprivation therapy (ADT) and whether sleep impairment associates with depressive symptoms, cognitive function or frailty syndrome, and if this varies between patients with localized or metastatic disease. The pro-inflammatory cytokine, IL-1β is involved in sleep regulation, we assessed whether sleep quality, depressive symptoms, cognitive function or frailty syndrome are associated with IL-1β concentration.

Methods

Sleep quality was assessed using the Athens Insomnia Scale (AIS), depressive symptoms using the Yesavage Scale (GDS), and cognitive functions using the MiniMental State Exam (MMSE) and the level of frailty was measured based on the Fried criteria. Plasma IL-1β was measured by enzyme-linked immunoassay. Linear regression lanalyses were performed to determine which variables predict plasma IL-1β is involved in poor sleep quality and higher IL-1β concentration.

Results

A cross-sectional study was carried out between 2021 and 2023. Sixty-seven men with PCa (N=36 (53.7%) with localized disease and N=31 (46.3%) with metastatic disease) were enrolled in the study. Plasma IL-1β concentration correlated with poorer sleep quality in all sample and, men with metastatic PCa had poorer sleep quality compared to men with localized disease. Analysis of self-reported sleep quality revealed that half of them had insomnia symptoms and 19.4% reported clinically relevant insomnia disorder (mean value of AIS 3.39±0.44). Poor sleep quality significantly predicted the concentration of IL-1β in plasma. In contrast, a better cognitive function significantly (P = .037) predicted IL-1β concentration. Detailed analysis of AIS items showed that score in the item “Sleep induction” and “Sleepiness during the da) significantly predicted IL-1β concentrations (P = .001 and P0=.044, respectively).

Conclusions

Plasma IL-1β levels may be useful to address the presence of insomnia in patients with PCa who are receiving ADT and to monitor the effect of interventions to improve sleep problems in these patients.

Implications for Nursing Practice

Nurses will play a critical role in educating patients about their risk for specific symptoms based on an evaluation of specific biomarkers such as IL-1β and sleep quality. Nurses will be involved in using biomarker data to titrate medications and to evaluate the effect of nonpharmacological interventions to improve sleep quality in patients with PCa.
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来源期刊
Seminars in Oncology Nursing
Seminars in Oncology Nursing Nursing-Oncology (nursing)
CiteScore
3.40
自引率
0.00%
发文量
68
审稿时长
45 days
期刊介绍: Seminars in Oncology Nursing is a unique international journal published six times a year. Each issue offers a multi-faceted overview of a single cancer topic from a selection of expert review articles and disseminates oncology nursing research relevant to patient care, nursing education, management, and policy development.
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