是什么预示着新近确诊的多发性硬化症患者工作环境的变化?这些预示因素是否也适用于健康人?

IF 2.5 3区 医学 Q1 REHABILITATION
Shalina R D Saddal, Karin van der Hiele, Ehsan Motazedi, Elianne E A van Egmond, Leo H Visser, Pauline T Waskowiak, Amber van der Kruit, Maureen van Dam, Menno M Schoonheim, Vincent de Groot, Hanneke E Hulst, Frederieke G Schaafsma
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引用次数: 0

摘要

目的:研究最近诊断的多发性硬化症(PwMS)患者一年后工作困难和工作小时数与基线预测因素的关系。此外,分析这些预测因子是否具有普遍性,即同样适用于健康人,还是针对特定疾病。方法:结合TEMPRANO和MS@Work数据,得出135例新近诊断的PwMS(≤1年)和172例健康人群的数据集。我们分析了符合国际功能和健康分类(ICF)框架的基线预测因子的关联,使用了一年后工作困难和工作小时数具有对数链接的混合效应负二项模型,并使用完全贝叶斯方法拟合每个模型。结果:较慢的信息处理速度是一年后更多工作困难的疾病特异性预测因子(后验平均比(PMR) = 0.82, 95%可信区间(CI) =[0.69, 0.97])。较高的责任心是一年后工作时间增加的一般预测因子(PwMS的PMR = 1.02, 95%CI =[1.01, 1.03],健康人的PMR = 1.01, 95%CI =[1.00, 1.02])。男性(PMR = 0.75, 95% CI =[0.58, 0.96])、较年轻(PMR = 0.99, 95% CI =[0.98, 1.00])、较高的信息处理速度(PMR = 1.08, 95% CI =[1.04, 1.13])、较好的学习和记忆(PMR = 1.09, 95% CI =[1.03, 1.15])、精神负担重的工作任务(PMR = 1.36, 95% CI =[1.22, 1.52])是一年后工作时间增加的疾病特异性预测因素。结论:对于最近诊断的PwMS,符合ICF框架的疾病特异性预测因子与一年后感知到的工作困难和工作时间有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What Predicts Changes in the Work Situation of Recently Diagnosed People with Multiple Sclerosis and do these Predictors also Apply to Healthy People?

Purpose: To study associations of baseline predictors with work difficulties and number of working hours after one year in recently diagnosed people with multiple sclerosis (PwMS). Furthermore, to analyze whether these predictors are generic, i.e., apply to healthy people as well, or are disease specific.

Methods: TEMPRANO and MS@Work data were combined resulting in a dataset of 135 recently diagnosed PwMS (≤ 1 year) and 172 healthy people. We analyzed the associations of baseline predictors that fit within the international classification of functioning and health (ICF) framework using a mixed-effect negative-binomial model with log link for work difficulties and number of working hours after one year, and fitted each model using a fully Bayesian approach.

Results: Slower information processing speed was a disease-specific predictor for more work difficulties after one year (posterior mean ratio (PMR) = 0.82, 95% confidence interval (CI) = [0.69, 0.97]). Higher conscientiousness was a generic predictor for more working hours after one year (PMR = 1.02, 95%CI = [1.01, 1.03] for PwMS and PMR = 1.01, 95% CI = [1.00, 1.02] for healthy people). Being male (PMR = 0.75, 95% CI = [0.58, 0.96]), being younger (PMR = 0.99, 95% CI = [0.98, 1.00]), higher information processing speed (PMR = 1.08, 95% CI = [1.04, 1.13]), better learning and memory (PMR = 1.09, 95% CI = [1.03, 1.15]), and mentally burdensome job tasks (PMR = 1.36, 95% CI = [1.22, 1.52]) were disease-specific predictors for more working hours after one year.

Conclusion: For recently diagnosed PwMS, disease-specific predictors that fit within the ICF framework associate with perceived work difficulties and working hours after one year.

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来源期刊
CiteScore
5.80
自引率
12.10%
发文量
64
期刊介绍: The Journal of Occupational Rehabilitation is an international forum for the publication of peer-reviewed original papers on the rehabilitation, reintegration, and prevention of disability in workers. The journal offers investigations involving original data collection and research synthesis (i.e., scoping reviews, systematic reviews, and meta-analyses). Papers derive from a broad array of fields including rehabilitation medicine, physical and occupational therapy, health psychology and psychiatry, orthopedics, oncology, occupational and insurance medicine, neurology, social work, ergonomics, biomedical engineering, health economics, rehabilitation engineering, business administration and management, and law.  A single interdisciplinary source for information on work disability rehabilitation, the Journal of Occupational Rehabilitation helps to advance the scientific understanding, management, and prevention of work disability.
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