睡眠时间和睡眠困难对慢性肾病患者虚弱的相互作用:来自NHANES的研究结果,2005-2018。

IF 3 3区 医学 Q1 UROLOGY & NEPHROLOGY
Renal Failure Pub Date : 2025-12-01 Epub Date: 2025-02-27 DOI:10.1080/0886022X.2025.2471008
Xi-Zhe Zhang, Jiong-Ao Xiang, Jun-Jie Xu, Wen-Feng Wang, Yao-Dong Li
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引用次数: 0

摘要

背景:睡眠障碍和慢性肾脏疾病(CKD)都被认为是重要的公共卫生问题。在一般人群中,睡眠障碍已被证明与老年人身体虚弱有关。本研究旨在评估CKD患者睡眠时间和睡眠困难与虚弱之间的关系,以及两者之间潜在的相互作用。方法:本横断面研究分析了2005-2018年国家健康与营养检查调查(NHANES)的数据。睡眠时间和睡眠问题都是自我报告的。虚弱是用49项虚弱指数来评估的。使用加权多元逻辑回归和限制三次样条分析睡眠时间、睡眠困难和虚弱之间的关系。进行亚组分析以确定研究结论在不同亚组间的一致性。结果:共有5211名成人CKD患者被纳入本分析。回归分析结果显示,短睡眠时间(OR = 1.364, 95% CI: 1.152-1.616)、长睡眠时间(OR = 1.648, 95% CI: 1.259-2.157)和睡眠困难(OR = 2.572, 95% CI: 2.102-3.147)与CKD患者虚弱风险增加显著相关,且睡眠时间和睡眠困难之间存在交互作用。亚组分析显示,睡眠困难和睡眠持续时间对CKD患者虚弱症状的影响在不同年龄组中表现出显著差异(p)。结论:我们的研究结果表明,睡眠持续时间和睡眠困难与CKD患者虚弱显著相关,这两个因素之间存在显著的相互作用。因此,CKD患者虚弱的预防和干预策略应涉及睡眠健康的多个方面。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Interactive effect of sleep duration and trouble sleeping on frailty in chronic kidney disease: findings from NHANES, 2005-2018.

Background: Both sleep disorders and chronic kidney disease (CKD) are recognized as significant public health concerns. In the general population, sleep disorders have been shown to be associated with frailty in the elderly. This study aims to evaluate the association between sleep duration and trouble sleeping with frailty in CKD patients, as well as the potential interactive effect between these two factors.

Methods: This cross-sectional study analyzed data from the National Health and Nutrition Examination Survey (NHANES) spanning 2005-2018. Sleep duration and trouble sleeping was self-reported. Frailty was assessed using a 49-item frailty index. The associations between sleep duration, trouble sleeping, and frailty were analyzed using weighted multivariate logistic regression and restricted cubic splines. Subgroup analysis was conducted to determine the consistency of the study's conclusions across various subgroups.

Results: A total of 5,211 adult CKD patients were included in this analysis. Regression analysis results indicated that short sleep duration (OR = 1.364, 95% CI: 1.152-1.616), long sleep duration (OR = 1.648, 95% CI: 1.259-2.157), and trouble sleeping (OR = 2.572, 95% CI: 2.102-3.147) were significantly associated with an increased risk of frailty in CKD patients, with an interaction between sleep duration and trouble sleeping. Subgroup analysis revealed that the effects of trouble sleeping and sleep duration on frailty symptoms in CKD patients exhibit significant variation across age groups (p < 0.05 for interaction), with no notable differences observed in other subgroups. RCS results demonstrated a U-shaped relationship between frailty and sleep duration, with the lowest risk of frailty at 7.12 h of sleep.

Conclusion: Our findings indicated that both sleep duration and trouble sleeping were significantly associated with frailty in CKD patients, with a notable interaction between these two factors. Therefore, prevention and intervention strategies for frailty in CKD patients should address multiple aspects of sleep health.

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来源期刊
Renal Failure
Renal Failure 医学-泌尿学与肾脏学
CiteScore
3.90
自引率
13.30%
发文量
374
审稿时长
1 months
期刊介绍: Renal Failure primarily concentrates on acute renal injury and its consequence, but also addresses advances in the fields of chronic renal failure, hypertension, and renal transplantation. Bringing together both clinical and experimental aspects of renal failure, this publication presents timely, practical information on pathology and pathophysiology of acute renal failure; nephrotoxicity of drugs and other substances; prevention, treatment, and therapy of renal failure; renal failure in association with transplantation, hypertension, and diabetes mellitus.
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