2024 ILTS-ILCA共识建议肝移植治疗肝细胞癌和肝内胆管癌。

IF 4.7 2区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Liver Transplantation Pub Date : 2025-06-01 Epub Date: 2025-02-28 DOI:10.1097/LVT.0000000000000589
Sudha Kodali, Laura Kulik, Antonio D'Allessio, Eleonora De Martin, Abdul Rahman Hakeem, Monica Lewinska, Stacie Lindsey, Ken Liu, Zorana Maravic, Madhukar S Patel, David Pinato, Ashwin Rammohan, Nicole Rich, Marco Sanduzzi Zamparelli, David W Victor, Carmen Vinaxia, Elizabeth W Brombosz, Augusto Villanueva, Tim Meyer, Nazia Selzner, Rafik Mark Ghobrial, Mohamed Rela, Gonzalo Sapisochin
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引用次数: 0

摘要

背景:肝移植(LT)为肝癌患者提供了最佳的长期生存结果。因此,在过去的几十年里,移植肿瘤学领域有了很大的发展,许多中心已经扩大了他们的标准,允许更多的肝恶性肿瘤患者接受肝移植。移植肿瘤学的中心指南和实践在世界各地有很大的不同,这导致了对这一患者群体的最佳治疗方案的争论。方法:国际肝移植学会和国际肝癌协会于2024年2月1日至2日在西班牙瓦伦西亚召开了一次国际共识会议,以建立关于肿瘤适应症肝移植的更普遍共识。会议遵循德尔菲程序,然后是外部专家审查。结果:关于患者评估和等待名单标准、移植前治疗(包括免疫治疗)和降期、活体供体肝移植、肝移植后患者管理以及患者和护理人员相关结果的共识声明被接受。结论:共识会议的多学科参与者提供了关于考虑肝移植的肝癌患者的选择和管理的最新建议。尽管在许多情况下,参与者推迟了中心协议,但对于肿瘤负担较大和生物学上可适应病变的患者,安全扩大肝移植的范围非常有兴趣。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The 2024 ILTS-ILCA consensus recommendations for liver transplantation for HCC and intrahepatic cholangiocarcinoma.

Liver transplantation (LT) provides the best long-term survival outcomes for patients with liver cancer. As a result, the field of transplant oncology has grown greatly over the past few decades, and many centers have expanded their criteria to allow increased access to LT for liver malignancies. Center-level guidelines and practices in transplant oncology significantly vary across the world, leading to debate regarding the best course of treatment for this patient population. An international consensus conference was convened by the International Liver Transplantation Society and the International Liver Cancer Association on February 1-2, 2024, in Valencia, Spain to establish a more universal consensus regarding LT for oncologic indications. The conference followed the Delphi process, followed by an external expert review. Consensus statements were accepted regarding patient assessment and waitlisting criteria, pretransplant treatment (including immunotherapy) and downstaging, living donor LT, post-LT patient management, and patient- and caregiver-related outcomes. The multidisciplinary participants in the consensus conference provided up-to-date recommendations regarding the selection and management of patients with liver cancer being considered for LT. Although participants deferred to center protocols in many cases, there was great interest in safely expanding access to LT for patients with larger tumor burden and biologically amenable lesions.

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来源期刊
Liver Transplantation
Liver Transplantation 医学-外科
CiteScore
7.40
自引率
6.50%
发文量
254
审稿时长
3-8 weeks
期刊介绍: Since the first application of liver transplantation in a clinical situation was reported more than twenty years ago, there has been a great deal of growth in this field and more is anticipated. As an official publication of the AASLD, Liver Transplantation delivers current, peer-reviewed articles on liver transplantation, liver surgery, and chronic liver disease — the information necessary to keep abreast of this evolving specialty.
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