代谢健康的年轻亚裔美国人与肥胖的MASLD患病率及其相关性：全国住院患者视角（2019）

Obesity Pillars Pub Date : 2025-03-01 DOI:10.1016/j.obpill.2025.100168

Ahmad Alhomaid , Sukhjinder Chauhan , Yamini Katamreddy , Avideep Sidhu , Praveena Sunkara , Rupak Desai

{"title":"代谢健康的年轻亚裔美国人与肥胖的MASLD患病率及其相关性：全国住院患者视角（2019）","authors":"Ahmad Alhomaid , Sukhjinder Chauhan , Yamini Katamreddy , Avideep Sidhu , Praveena Sunkara , Rupak Desai","doi":"10.1016/j.obpill.2025.100168","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide. Although the epidemiology of MASLD and its association with metabolically healthy obesity (MHO) is well-studied in the United States, data for Asian Americans with MHO is limited. We sought to evaluate the association of MASLD in young Asian American patients with MHO.</div></div><div><h3>Methods</h3><div>This was a retrospective, matched cohort, database review of Asian American Individuals. After excluding adult hospitalizations with metabolic risk factors (hypertension, diabetes, or hyperlipidemia), we identified all National Inpatient Sample (2019) admissions with obesity (MHO) and MASLD using relevant ICD-10-CM codes. We matched (1:1) propensity scores for age, sex, household income, hospital location, and teaching status to obtain cohorts with and without obesity (MHO+) vs. (MHO-). Categorical and continuous data were compared using the Chi-square and Mann-Whitney U tests. The primary endpoint was the prevalence and adjusted multivariable odds/predictors of MASLD in (MHO+) vs. (MHO-) cohort.</div></div><div><h3>Results</h3><div>In the adjusted multivariate regression for demographics, and comorbidities, the (MHO+) cohort was associated with higher odds of admissions with MASLD (OR 4.07, 95%CI 2.02–8.19, p < 0.001). In addition, among the (MHO+) cohort, higher rates of MASLD-related hospitalizations were observed in males (OR 8.40, p < 0.001), females (OR 2.69, p = 0.025), high-income quartiles (OR 10.51, p < 0.001), no prior bariatric surgery (OR 4.07, p < 0.001), non-tobacco users(OR 4.16, p < 0.001), and non-hypothyroid patients (OR 4.00, p < 0.001) compared to the (MHO-) cohort. There was no statistically significant difference in the groups with low-income quartiles, tobacco use disorder, and hypothyroidism.</div></div><div><h3>Conclusion</h3><div>This nationwide analysis demonstrates that (MHO+) is associated with a higher prevalence of MASLD. In the (MHO+) cohort, there was an association of MASLD with sex, high-income quartile, no prior bariatric surgery, non-tobacco use, and non-hypothyroidism. Further prospective multicenter studies are needed to evaluate the association of MASLD in (MHO+) patients with comorbid conditions.</div></div>","PeriodicalId":100977,"journal":{"name":"Obesity Pillars","volume":"13 ","pages":"Article 100168"},"PeriodicalIF":0.0000,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prevalence and association of MASLD in metabolically healthy young Asian Americans with obesity: A nationwide inpatient perspective (2019)\",\"authors\":\"Ahmad Alhomaid , Sukhjinder Chauhan , Yamini Katamreddy , Avideep Sidhu , Praveena Sunkara , Rupak Desai\",\"doi\":\"10.1016/j.obpill.2025.100168\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide. Although the epidemiology of MASLD and its association with metabolically healthy obesity (MHO) is well-studied in the United States, data for Asian Americans with MHO is limited. We sought to evaluate the association of MASLD in young Asian American patients with MHO.</div></div><div><h3>Methods</h3><div>This was a retrospective, matched cohort, database review of Asian American Individuals. After excluding adult hospitalizations with metabolic risk factors (hypertension, diabetes, or hyperlipidemia), we identified all National Inpatient Sample (2019) admissions with obesity (MHO) and MASLD using relevant ICD-10-CM codes. We matched (1:1) propensity scores for age, sex, household income, hospital location, and teaching status to obtain cohorts with and without obesity (MHO+) vs. (MHO-). Categorical and continuous data were compared using the Chi-square and Mann-Whitney U tests. The primary endpoint was the prevalence and adjusted multivariable odds/predictors of MASLD in (MHO+) vs. (MHO-) cohort.</div></div><div><h3>Results</h3><div>In the adjusted multivariate regression for demographics, and comorbidities, the (MHO+) cohort was associated with higher odds of admissions with MASLD (OR 4.07, 95%CI 2.02–8.19, p < 0.001). In addition, among the (MHO+) cohort, higher rates of MASLD-related hospitalizations were observed in males (OR 8.40, p < 0.001), females (OR 2.69, p = 0.025), high-income quartiles (OR 10.51, p < 0.001), no prior bariatric surgery (OR 4.07, p < 0.001), non-tobacco users(OR 4.16, p < 0.001), and non-hypothyroid patients (OR 4.00, p < 0.001) compared to the (MHO-) cohort. There was no statistically significant difference in the groups with low-income quartiles, tobacco use disorder, and hypothyroidism.</div></div><div><h3>Conclusion</h3><div>This nationwide analysis demonstrates that (MHO+) is associated with a higher prevalence of MASLD. In the (MHO+) cohort, there was an association of MASLD with sex, high-income quartile, no prior bariatric surgery, non-tobacco use, and non-hypothyroidism. Further prospective multicenter studies are needed to evaluate the association of MASLD in (MHO+) patients with comorbid conditions.</div></div>\",\"PeriodicalId\":100977,\"journal\":{\"name\":\"Obesity Pillars\",\"volume\":\"13 \",\"pages\":\"Article 100168\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-03-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Obesity Pillars\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2667368125000129\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Pillars","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2667368125000129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

背景：代谢功能障碍相关脂肪变性肝病（MASLD）是世界范围内慢性肝病的主要原因。尽管MASLD的流行病学及其与代谢健康型肥胖（MHO）的关系在美国得到了充分的研究，但关于MHO的亚裔美国人的数据有限。我们试图评估年轻亚裔美国人MHO患者与MASLD的关系。方法对亚裔美国人进行回顾性、匹配队列、数据库回顾。在排除了伴有代谢危险因素（高血压、糖尿病或高脂血症）的成人住院患者后，我们使用相关的ICD-10-CM代码确定了所有患有肥胖症（MHO）和MASLD的全国住院患者样本（2019）。我们将年龄、性别、家庭收入、医院位置和教学状况的倾向评分（1:1）进行匹配，以获得有肥胖和没有肥胖的队列（MHO+）和（MHO-）。分类数据和连续数据采用卡方检验和Mann-Whitney U检验进行比较。主要终点是（MHO+）与（MHO-）队列中MASLD的患病率和调整后的多变量赔率/预测因子。结果在人口统计学和合并症的调整多因素回归中，（MHO+）队列与MASLD入院几率较高相关(OR 4.07, 95%CI 2.02-8.19, p <；0.001)。此外，在（MHO+）队列中，男性与masld相关的住院率较高(OR 8.40, p <；0.001)，女性（OR 2.69, p = 0.025），高收入四分位数(OR 10.51, p <；0.001)，既往无减肥手术(OR 4.07, p <；0.001)，非烟草使用者(OR 4.16, p <；0.001)，非甲状腺功能减退患者(OR 4.00, p <；0.001)，与（MHO-）队列相比。在低收入四分位数组、烟草使用障碍组和甲状腺功能减退组中，没有统计学上的显著差异。结论全国范围内的分析表明（MHO+）与MASLD的高患病率相关。在（MHO+）队列中，MASLD与性别、高收入四分位数、既往无减肥手术、非吸烟和非甲状腺功能减退有关。需要进一步的前瞻性多中心研究来评估MASLD在（MHO+）合并合并症患者中的相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Prevalence and association of MASLD in metabolically healthy young Asian Americans with obesity: A nationwide inpatient perspective (2019)

查看原文本刊更多论文

Prevalence and association of MASLD in metabolically healthy young Asian Americans with obesity: A nationwide inpatient perspective (2019)

Background

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide. Although the epidemiology of MASLD and its association with metabolically healthy obesity (MHO) is well-studied in the United States, data for Asian Americans with MHO is limited. We sought to evaluate the association of MASLD in young Asian American patients with MHO.

Methods

This was a retrospective, matched cohort, database review of Asian American Individuals. After excluding adult hospitalizations with metabolic risk factors (hypertension, diabetes, or hyperlipidemia), we identified all National Inpatient Sample (2019) admissions with obesity (MHO) and MASLD using relevant ICD-10-CM codes. We matched (1:1) propensity scores for age, sex, household income, hospital location, and teaching status to obtain cohorts with and without obesity (MHO+) vs. (MHO-). Categorical and continuous data were compared using the Chi-square and Mann-Whitney U tests. The primary endpoint was the prevalence and adjusted multivariable odds/predictors of MASLD in (MHO+) vs. (MHO-) cohort.

Results

In the adjusted multivariate regression for demographics, and comorbidities, the (MHO+) cohort was associated with higher odds of admissions with MASLD (OR 4.07, 95%CI 2.02–8.19, p < 0.001). In addition, among the (MHO+) cohort, higher rates of MASLD-related hospitalizations were observed in males (OR 8.40, p < 0.001), females (OR 2.69, p = 0.025), high-income quartiles (OR 10.51, p < 0.001), no prior bariatric surgery (OR 4.07, p < 0.001), non-tobacco users(OR 4.16, p < 0.001), and non-hypothyroid patients (OR 4.00, p < 0.001) compared to the (MHO-) cohort. There was no statistically significant difference in the groups with low-income quartiles, tobacco use disorder, and hypothyroidism.

Conclusion

This nationwide analysis demonstrates that (MHO+) is associated with a higher prevalence of MASLD. In the (MHO+) cohort, there was an association of MASLD with sex, high-income quartile, no prior bariatric surgery, non-tobacco use, and non-hypothyroidism. Further prospective multicenter studies are needed to evaluate the association of MASLD in (MHO+) patients with comorbid conditions.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Obesity Pillars

自引率

0.00%

发文量