基于社区的对内分泌干扰化学物质和抑郁症状之间联系的见解

IF 2.9 Q2 TOXICOLOGY

Current Research in Toxicology Pub Date : 2025-01-01 DOI:10.1016/j.crtox.2025.100225

Yun-An Liu , Heng-Jung Hsu , Heng-Chih Pan , Chiao-Yin Sun , Yih-Ting Chen , Chin-Chan Lee , Feng-Chieh Su , Yi-Chia Wei , Cheng-Kai Hsu , Chun-Yu Chen

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引用次数: 0

摘要

抑郁症患病率的上升引发了人们对环境风险因素的关注，特别是暴露于内分泌干扰化学物质（EDCs）。然而，EDC暴露与抑郁症状之间的联系在很大程度上仍未被探索。方法长庚社区医学研究中心在台湾东北部四个地区进行横断面研究。在887名参与者中，根据他们的EDC暴露分数选择了120名受试者。这些参与者接受了尿EDC分析，并通过标准化的医院焦虑和抑郁量表-抑郁子量表（HADS-D）问卷评估抑郁症状。结果HADS-D评分≥8分的受试者EDC暴露评分明显高于低评分的受试者。相关性分析发现尿邻苯二甲酸一苯酯（MBzP）水平与HADS-D评分之间存在显著正相关（r = 0.244, p = 0.007）。多元回归分析显示，MBzP与HADS-D评分升高呈独立正相关（β±SE: 0.139±0.050,p = 0.006）。多变量logistic回归显示MBzP （OR: 1.150, 95% CI: 1.036-1.278, p = 0.009）和对羟基苯甲酸甲酯（MP）水平较高(OR: 1.008, 95% CI: 1.003-1.013, p <；0.001)与HADS-D评分≥8的可能性有显著相关性。受试者工作特征曲线分析表明，MBzP、MP和EDCs暴露评分水平的升高与抑郁症状的可能性增加有关。结论暴露于EDCs，特别是MBzP和MP，可能与抑郁症状的风险增加有关。

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Community-based insights into the connection between endocrine-disrupting chemicals and depressive symptoms

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Community-based insights into the connection between endocrine-disrupting chemicals and depressive symptoms

Background

The rising prevalence of depressive disorders has sparked concerns regarding environmental risk factors, particularly exposure to endocrine-disrupting chemicals (EDCs). However, the link between EDC exposure and depressive symptoms remains largely unexplored.

Methods

The Chang Gung Community Medicine Research Center carried out a cross-sectional study across four regions in northeastern Taiwan. Out of 887 participants, 120 subjects were chosen according to their EDC exposure scores. These participants underwent urinary EDC analysis and were evaluated for depressive symptoms through the standardized Hospital Anxiety and Depression Scale − Depression subscale (HADS-D) questionnaire.

Results

Participants with HADS-D scores ≥ 8 exhibited significantly higher EDC exposure score compared to those with lower scores. The correlation analyses identified a notible positive association between urinary monobenzyl phthalate (MBzP) levels and HADS-D scores (r = 0.244, p = 0.007). Multiple regression analysis revealed that MBzP was independently linked to increased HADS-D scores in a positive manner (β ± SE: 0.139 ± 0.050, p = 0.006). Multivariable logistic regression indicated that higher MBzP (OR: 1.150, 95 % CI: 1.036–1.278, p = 0.009) and methylparaben (MP) levels (OR: 1.008, 95 % CI: 1.003–1.013, p < 0.001) showed a significant correlation with the likelihood of HADS-D scores ≥ 8. Receiver operating characteristic curve analysis demonstrated that elevated levels of MBzP, MP and the EDCs exposure score were associated with a greater likelihood of depressive symptoms.