呼出的挥发性有机化合物与慢性阻塞性肺疾病加重相关——系统评价和验证

IF 3.7 4区 医学 Q1 BIOCHEMICAL RESEARCH METHODS
Jorrit van Poelgeest, Shahriyar Shahbazi Khamas, Ahmed Hallawa, Cristian D'Alessandro, Ricardo Ferreira, Anke H Maitland-van der Zee, Paul Brinkman
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引用次数: 0

摘要

理由:慢性阻塞性肺疾病(COPD)的恶化显著促进疾病进展、住院治疗和生活质量下降。通过非侵入性方法(如呼出的挥发性有机化合物(VOCs))早期发现病情恶化,可以实现及时干预。本研究旨在确定和验证与COPD加重期和稳定期相关的候选VOC生物标志物,并可能有助于开发基于呼吸的监测设备。方法:进行系统综述以确定与COPD和加重期相关的VOC。如果VOCs被不同的研究小组在至少两项研究中报告,则被选为候选生物标志物。然后使用TEXACOLD研究中的纵向呼气数据验证这些VOCs,其中在基线,加重期间和随访期间收集14名COPD患者的呼气样本。采用稀疏偏最小二乘判别分析(sPLS-DA)对急性加重期和稳定期采集的样本进行区分。使用受试者工作特征(ROC)曲线评估诊断准确性。结果:系统评价确定了9种候选挥发性有机化合物。其中三人被排除在验证之外,因为他们的数据集与其中一项纳入的综述研究中使用的数据集重叠。验证证实了这六种VOCs的复合模型的鉴别能力,其ROC曲线下面积为0.98,诊断准确率为94.3%,灵敏度为0.97,特异性为0.93。结论:本研究表明,呼出VOCs可以区分COPD患者的加重期和稳定期。这些经过验证的生物标志物有望在未来的临床应用中得到应用,特别是在开发一种无创、基于呼吸的监测设备,用于COPD恶化的早期检测和管理,有可能减少住院治疗并改善患者的预后。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Exhaled volatile organic compounds associated with chronic obstructive pulmonary disease exacerbations-a systematic review and validation.

Chronic obstructive pulmonary disease (COPD) exacerbations significantly contribute to disease progression, hospitalizations, and decreased quality of life. Early detection of exacerbations through non-invasive methods, such as exhaled volatile organic compounds (VOCs), could enable timely interventions. This study aimed to identify and validate candidate VOC biomarkers that are associated with exacerbations and stable phases of COPD, and could contribute to the development of a breath-based monitoring device. A systematic review was conducted to identify VOCs associated with COPD and exacerbations. VOCs were selected as candidate biomarkers if they were reported in at least two studies by different research groups. These VOCs were then validated using longitudinal exhaled breath data from the TEXACOLD study, where exhaled breath samples were collected at baseline, during exacerbation, and at follow-up in 14 COPD patients. Sparse partial least squares-discriminant analysis was applied to differentiate between samples collected during exacerbation and those at stable phases. Diagnostic accuracy was assessed using receiver operating characteristic (ROC) curves. The systematic review identified nine candidate VOCs. Three were excluded from validation because their dataset overlapped with one used in one of the included review studies. Validation confirmed the discriminatory power of a composite model of these six VOCs, achieving an area under the ROC curve of 0.98, a diagnostic accuracy of 94.3% and a sensitivity of 0.97 and a specificity of 0.93. This study demonstrates that exhaled VOCs can differentiate between exacerbations and stable phases in COPD patients. The validated biomarkers hold promise for future clinical applications, particularly in the development of a non-invasive, breath-based monitoring device for early detection and management of COPD exacerbations, potentially reducing hospitalizations and improving patient outcomes.

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来源期刊
Journal of breath research
Journal of breath research BIOCHEMICAL RESEARCH METHODS-RESPIRATORY SYSTEM
CiteScore
7.60
自引率
21.10%
发文量
49
审稿时长
>12 weeks
期刊介绍: Journal of Breath Research is dedicated to all aspects of scientific breath research. The traditional focus is on analysis of volatile compounds and aerosols in exhaled breath for the investigation of exogenous exposures, metabolism, toxicology, health status and the diagnosis of disease and breath odours. The journal also welcomes other breath-related topics. Typical areas of interest include: Big laboratory instrumentation: describing new state-of-the-art analytical instrumentation capable of performing high-resolution discovery and targeted breath research; exploiting complex technologies drawn from other areas of biochemistry and genetics for breath research. Engineering solutions: developing new breath sampling technologies for condensate and aerosols, for chemical and optical sensors, for extraction and sample preparation methods, for automation and standardization, and for multiplex analyses to preserve the breath matrix and facilitating analytical throughput. Measure exhaled constituents (e.g. CO2, acetone, isoprene) as markers of human presence or mitigate such contaminants in enclosed environments. Human and animal in vivo studies: decoding the ''breath exposome'', implementing exposure and intervention studies, performing cross-sectional and case-control research, assaying immune and inflammatory response, and testing mammalian host response to infections and exogenous exposures to develop information directly applicable to systems biology. Studying inhalation toxicology; inhaled breath as a source of internal dose; resultant blood, breath and urinary biomarkers linked to inhalation pathway. Cellular and molecular level in vitro studies. Clinical, pharmacological and forensic applications. Mathematical, statistical and graphical data interpretation.
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