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IF 0.9 4区农林科学 Q2 Veterinary

Journal of the South African Veterinary Association-Tydskrif Van Die Suid-A Pub Date : 2024-12-01 DOI:10.36303/JSAVA.627

S B Harris, E H Hooijberg, S J Clift, G T Fosgate, Y Rautenbach

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引用次数: 0

摘要

据报道，不同地区的犬只在品种、年龄和性别上都有患淋巴瘤的倾向。然而，南非犬淋巴瘤的流行病学资料却很少。本研究旨在描述南非犬淋巴瘤的流行病学特征以及世界卫生组织（WHO）分类亚型的发生频率。这项回顾性病例对照研究包括342例组织病理学诊断为犬淋巴瘤的病例和342例犬非淋巴瘤对照病例。研究采用单变量和多变量条件逻辑回归法评估了犬淋巴瘤与犬种、年龄、性别和绝育状况之间的关系。相关性以几率比的形式报告，显著性设定为 p≤ 0.05。犬种与犬淋巴瘤密切相关，但与年龄、性别或绝育状况无关。中位年龄为 8 岁，男女比例为 1.2:1。波尔波尔犬患犬淋巴瘤的风险增加（OR = 1.63，CI = 1.02-2.62，p = 0.002），约克夏梗患犬淋巴瘤的风险降低（OR = 0.59，CI = 0.38-0.93，p = 0.050）。对 119 例（35%）病例进行了免疫分型，其中 82 例（69%）为 B 细胞淋巴瘤，34 例（29%）为 T 细胞淋巴瘤，3 例（2%）两者均不是。88例病例有WHO亚型，其中66例（75%）为弥漫大B细胞淋巴瘤（DLBCL），其余亚型的比例均低于7%。这项研究发现，南非獒犬波尔波尔犬（Boerboel）易患犬淋巴瘤，但未发现与年龄、性别和其他犬种有显著关联。免疫表型和世卫组织亚型的频率与之前在其他地方进行的研究相似。

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An epidemiological study of canine lymphoma in South Africa.

Breed, age, and sex predispositions for canine lymphoma have been reported for various geographical locations. However, epidemiological information concerning canine lymphoma in South Africa is scarce. The aim of the study was to describe the epidemiological features of canine lymphoma and the frequency of World Health Organization (WHO) classification subtypes in South Africa. A retrospective, case-control study was performed that included 342 cases with a histopathological diagnosis of canine lymphoma matched with 342 canine non-lymphoma control cases. Associations between canine lymphoma and breed, age, sex, and neutering status were assessed using univariate and multivariable conditional logistic regression. Associations were reported as odds ratios and significance set as p≤ 0.05. Breed was significantly associated with canine lymphoma, but not age, sex, or neutering status. Median population age was eight years, with a male-to-female ratio of 1.2:1. The Boerboel had an increased risk (OR = 1.63, CI = 1.02-2.62, p = 0.002) and the Yorkshire Terrier a decreased risk (OR = 0.59, CI = 0.38-0.93, p = 0.050) of having canine lymphoma. Immunophenotyping was performed on 119 (35%) cases, of which 82 (69%) were B-cell, 34 (29%) T-cell and three (2%) neither. WHO subtype was available for 88 cases; of these 66 (75%) were diffuse large B-cell lymphoma (DLBCL) with remaining subtypes each ≤ 7%. This study identified a breed predisposition for canine lymphoma in the Boerboel, a South African mastiff-type dog, but significant associations were not detected for age, sex, and other breeds. The frequency of immunophenotypes and WHO subtypes was similar to previous studies in other locations.

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来源期刊

Journal of the South African Veterinary Association-Tydskrif Van Die Suid-A 农林科学-兽医学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

22 weeks

期刊介绍： The Journal of the South African Veterinary Association is a contemporary multi-disciplinary scientific mouthpiece for Veterinary Science in South Africa and abroad. It provides veterinarians in South Africa and elsewhere in the world with current scientific information across the full spectrum of veterinary science. Its content therefore includes reviews on various topics, clinical and non-clinical articles, research articles and short communications as well as case reports and letters.