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IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Tomography Pub Date : 2025-02-07 DOI:10.3390/tomography11020016

Mayumi Higashi, Masahiro Tanabe, Katsuya Tanabe, Shigeru Okuya, Koumei Takeda, Yuko Nagao, Katsuyoshi Ito

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引用次数: 0

摘要

背景/目的：MRI 上与糖尿病相关的胰腺变化仍不清楚。因此，我们使用多参数 MRI 评估了 1 型糖尿病（T1D）和 2 型糖尿病（T2D）患者 MRI 上的胰腺变化：这项前瞻性研究涉及接受上腹部 3-T 磁共振成像检查的 1 型糖尿病或 2 型糖尿病患者。此外，还回顾性地纳入了没有糖代谢受损的患者作为对照。成像数据包括胰腺前胸（AP）直径、脂肪抑制 T1 加权成像（FS-T1WI）上的胰腺与肌肉信号强度比（SIR）、表观弥散系数（ADC）值、T1 图上的 T1 值、质子密度脂肪分数（PDFF）以及电影动态磁共振胰胆管造影（MRCP）上的胰液流平均分泌等级。采用单因素方差分析和 Kruskal-Wallis 检验对磁共振测量结果进行比较：对 61 名 T1D（n = 7）或 T2D（n = 54）患者和 21 名对照组患者进行了评估。T1D 患者的胰腺 AP 直径明显小于 T2D 患者（P < 0.05）。T1D 患者 FS-T1WI 的平均 SIR 值明显低于对照组（P < 0.001）。T1D患者胰腺的平均ADC和T1值明显高于T2D患者（P＜0.01）和对照组（P＜0.05）。T1D患者胰液流的平均分泌等级明显低于对照组（p = 0.019）。T2D患者胰腺的平均PDFF明显高于对照组（p = 0.029）：结论：T1D患者的胰腺体积缩小，胰腺T1和ADC值升高，胰液流经电影动态MRCP时减少，而T2D患者的胰腺脂肪含量升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Multiparametric Magnetic Resonance Imaging Findings of the Pancreas: A Comparison in Patients with Type 1 and 2 Diabetes.

Background/objectives: Diabetes-related pancreatic changes on MRI remain unclear. Thus, we evaluated the pancreatic changes on MRI in patients with both type 1 diabetes (T1D) and type 2 diabetes (T2D) using multiparametric MRI.

Methods: This prospective study involved patients with T1D or T2D who underwent upper abdominal 3-T MRI. Additionally, patients without impaired glucose metabolism were retrospectively included as a control. The imaging data included pancreatic anteroposterior (AP) diameter, pancreas-to-muscle signal intensity ratio (SIR) on fat-suppressed T1-weighted image (FS-T1WI), apparent diffusion coefficient (ADC) value, T1 value on T1 map, proton density fat fraction (PDFF), and mean secretion grade of pancreatic juice flow on cine-dynamic magnetic resonance cholangiopancreatography (MRCP). The MR measurements were compared using one-way analysis of variance and the Kruskal-Wallis test.

Results: Sixty-one patients with T1D (n = 7) or T2D (n = 54) and 21 control patients were evaluated. The pancreatic AP diameters were significantly smaller in patients with T1D than in patients with T2D (p < 0.05). The average SIR on FS-T1WI was significantly lower in patients with T1D than in controls (p < 0.001). The average ADC and T1 values of the pancreas were significantly higher in patients with T1D than in patients with T2D (p < 0.01) and controls (p < 0.05). The mean secretion grade of pancreatic juice flow was significantly lower in patients with T1D than in controls (p = 0.019). The average PDFF of the pancreas was significantly higher in patients with T2D than in controls (p = 0.029).

Conclusions: Patients with T1D had reduced pancreas size, increased pancreatic T1 and ADC values, and decreased pancreatic juice flow on cine-dynamic MRCP, whereas patients with T2D had increased pancreatic fat content.

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.