头颈部皮肤病变伴嗜酸性粒细胞增多。

IF 3.2 Q2 PATHOLOGY

Head & Neck Pathology Pub Date : 2025-02-25 DOI:10.1007/s12105-025-01757-3

David T Danielson, Ian Lagerstrom, Zachary Wary, Aaron Auerbach, David S Cassarino

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引用次数: 0

摘要

背景：头部和颈部有明显嗜酸性粒细胞浸润的皮肤病变代表了一组不同的疾病，从良性到恶性增生。方法：我们进行了全面的文献综述，重点是头颈部皮肤病，通常表现为突出的嗜酸性粒细胞浸润。结果：本综述概述了在该区域表现出显著相关嗜酸性粒细胞性炎症浸润的常见实体，包括上皮样血管瘤、嗜酸性蜂窝织炎（Wells综合征）、嗜酸性毛囊炎、嗜酸性肉芽肿伴多血管炎（Churg-Strauss综合征）、面部肉芽肿和朗格汉斯细胞组织细胞增多症（LCH）。结论：嗜酸性粒细胞在这些疾病的发病机制中起关键作用，尽管其确切机制尚不清楚。准确的诊断对于鉴别这些疾病至关重要，因为它们具有相似的组织学特征。本文综述旨在提高对这些嗜酸性皮肤疾病的认识，提高诊断准确性和治疗策略。

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Dermatologic Lesions with Eosinophilia in the Head and Neck.

Background: Dermatologic lesions with notable eosinophilic infiltration of the head and neck region represent a diverse group of conditions, ranging from benign to malignant proliferations.

Methods: We performed a comprehensive literature review focusing on head and neck dermatologic conditions that commonly present with a prominent eosinophilic infiltrate.

Results: This review provides an overview of common entities showing prominent associated eosinophilic inflammatory infiltrates in this region, including epithelioid hemangioma, eosinophilic cellulitis (Wells syndrome), eosinophilic folliculitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), granuloma faciale, and Langerhans cell histiocytosis (LCH).

Conclusion: Eosinophils play a key role in the pathogenesis of these disorders, although the exact mechanisms remain poorly understood. Accurate diagnosis is crucial for differentiating these conditions, as they can share similar histologic features. This review aims to enhance understanding of these eosinophilic dermatologic conditions, improving diagnostic accuracy and treatment strategies.

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来源期刊

Head & Neck Pathology PATHOLOGY-

CiteScore

5.70

自引率

9.50%

发文量

期刊介绍： Head & Neck Pathology presents scholarly papers, reviews and symposia that cover the spectrum of human surgical pathology within the anatomic zones of the oral cavity, sinonasal tract, larynx, hypopharynx, salivary gland, ear and temporal bone, and neck. The journal publishes rapid developments in new diagnostic criteria, intraoperative consultation, immunohistochemical studies, molecular techniques, genetic analyses, diagnostic aids, experimental pathology, cytology, radiographic imaging, and application of uniform terminology to allow practitioners to continue to maintain and expand their knowledge in the subspecialty of head and neck pathology. Coverage of practical application to daily clinical practice is supported with proceedings and symposia from international societies and academies devoted to this field. Single-blind peer review The journal follows a single-blind review procedure, where the reviewers are aware of the names and affiliations of the authors, but the reviewer reports provided to authors are anonymous. Single-blind peer review is the traditional model of peer review that many reviewers are comfortable with, and it facilitates a dispassionate critique of a manuscript.