c反应蛋白、国际标准化比值和纤维蛋白原在复杂急性阑尾炎诊断量表中的应用。

IF 1.7 Q2 MEDICINE, GENERAL & INTERNAL
Leticia Lorena Hernández-González, Said José Serrano-Guzmán, Jesús David Guzmán-Ortiz, Hermelo Esteban Pérez-Ceballos, José Luis Cano-Pérez, Víctor Cruz-Hernández, Héctor Ulises Bernardino-Hernández, Lucía Lourdes Martínez-Martínez, Sergio Roberto Aguilar-Ruiz
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引用次数: 0

摘要

背景/目的:鉴别复杂急性阑尾炎(CA)与非复杂急性阑尾炎(UC)对指导临床治疗具有重要意义。虽然CA需要紧急手术治疗,但UC可以在选定的病例中使用抗生素治疗。然而,准确识别CA仍然是一个临床挑战。本研究旨在确定与CA相关的因素,并制定诊断严重性量表。方法:在这项回顾性研究中,我们纳入了132例术后确诊为阑尾炎的成年患者(年龄在60岁至16岁之间),其中52例患有CA, 80例患有UA。评估体征、症状、合并症、实验室值和超声检查结果,以确定预测因素并构建诊断量表。结果:与CA最显著相关的因素是血浆c反应蛋白浓度升高(>7.150 mg/dL)、纤维蛋白原(481.5 mg/dL)、国际标准化比值(>1.150)和阑尾周围游离液体的存在。这些因素在一个量表内的组合曲线下面积(AUC)为0.84,灵敏度为78.75%,特异性为82.69%。结论:血清c反应蛋白浓度、纤维蛋白原、INR可单独或作为量表的一部分作为诊断CA的重要指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
C-Reactive Protein, International Normalized Ratio, and Fibrinogen in Diagnostic Scale of Complicated Acute Appendicitis.

Background/Objectives: Differentiating complicated acute appendicitis (CA) and uncomplicated acute appendicitis (UC) is essential to guide clinical management. While CA requires urgent surgical management, UC can be treated with antibiotic therapy in selected cases. However, accurate identification of CA remains a clinical challenge. This study aimed to identify factors associated with CA and to develop a diagnostic severity scale. Methods: In this retrospective study, we included 132 adult patients (>16 years) with a confirmed postsurgical diagnosis of appendicitis, of whom 52 had CA and 80 had UA. Signs, symptoms, comorbidities, laboratory values, and ultrasonographic findings were evaluated to determine predictive factors and construct a diagnostic scale. Results: The factors most significantly associated with CA were elevated plasma concentrations of C-reactive protein (>7.150 mg/dL), fibrinogen (481.5 mg/dL), International Normalized Ratio (INR) (>1.150), and the presence of free fluid periappendicular. The combination of these factors within one scale showed an area under the curve (AUC) of 0.84, with a sensitivity of 78.75% and a specificity of 82.69%. Conclusions: Serum C-reactive protein concentration, fibrinogen, and INR can be employed individually or as part of a scale as important indicators in diagnosing CA.

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来源期刊
Clinics and Practice
Clinics and Practice MEDICINE, GENERAL & INTERNAL-
CiteScore
2.60
自引率
4.30%
发文量
91
审稿时长
10 weeks
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