Bibliometric Analysis of Alpha-Synuclein Determination by Biopsy in Peripheral Tissues of Patients With Parkinson's Disease.

Study Evaluation: The bibliometric analysis of the published results of the alpha-synuclein (α-syn) detection study in the peripheral tissues of patients with Parkinson's disease was carried out by us to study scientific activity and scientific productivity, to measure the quantitative and qualitative characteristics of scientific publications, author productivity, and citation of works, as well as the degree of interrelation between authors, journals, institutes, and countries. Purpose: This study is aimed at bibliometrically analyzing the results of studies on the detection of α-syn in peripheral tissue biopsy of patients with Parkinson's disease from 2013 to 2023. Methods: The data was extracted from the Scopus database collection using an inclusive search strategy. Performance analysis and science mapping were conducted using RStudio v.4.3.1 with the bibliometrix R-package. The analyzed data encompassed trends in publication and citation and the identification of leading institutions, primary sources, authors, and collaborative countries. Results: A total of 124 relevant studies from 53 different sources were thoroughly analyzed. The analysis included the materials of 843 authors, which together gave an impressive average of 37.67 citations per document over the past decade. The annual growth rate in this area of research, according to calculations, was 10.84%, indicating a steady increase in the number of publications over the study period. The huge volume of research results is highlighted by the inclusion of 231 unique keywords of authors. Conclusion: Studies on the detection of pathological α-syn in peripheral tissues for early morphological verification of the diagnosis of Parkinson's disease are relevant in clinical neurology. α-syn detected in the skin biopsy of patients on the basis of this study and data from the world literature meets the requirements for biomarkers.