Pancreatic lipase inhibitors as anti-obesity agents: a review of recent chemical scaffolds and their pancreatic lipase inhibitory potential

Obesity is an excessive accumulation of fat in the body. The disease of obesity is increasing all over the world. At present, only a few drugs are available for the treatment of obesity. Various strategies have been explored for the management of obesity. The inhibition of fat metabolizing enzyme, pancreatic lipase (PL) is one of the best strategies for its treatment. In recent years, many organic compounds, heterocyclic and phytochemicals have been evaluated as PL inhibitors. The nitrogen-containing heterocyclic compounds have acquired great consideration due to their significant biological activities. Most of the compounds have been evaluated by in vitro and in silico experiments. The review highlights the PL inhibitory effects of different chemical scaffolds.