线粒体超氧化物调节促炎巨噬细胞

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2025-02-24 DOI:10.1038/s42255-025-01223-y

引用次数: 0

摘要

促炎巨噬细胞产生线粒体源性活性氧（mtROS），如超氧化物，但其如何产生或如何影响巨噬细胞效应功能尚不清楚。我们发现线粒体超氧化物是由呼吸链复合体I的反向电子传递产生的，并调节促炎细胞因子的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Mitochondrial superoxide regulates pro-inflammatory macrophages

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Mitochondrial superoxide regulates pro-inflammatory macrophages

Pro-inflammatory macrophages produce mitochondria-derived reactive oxygen species (mtROS) such as superoxide, but it is not understood how it is produced or how it affects macrophage effector functions. We show that mitochondrial superoxide is produced by reverse electron transport at complex I of the respiratory chain and regulates pro-inflammatory cytokine production.

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.