带静态角度调制端口的胸部和胸壁VMAT自动皮肤闪光优化:HU和闪光余量大小对平面质量和鲁棒性的影响

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Emily Hubley, Brandon Koger, Taoran Li, Michael Salerno, Ryan M Scheuermann, Lei Dong, Boon-Keng Kevin Teo
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引用次数: 0

摘要

皮肤闪光通常被添加到乳房和胸壁计划中,以确保在呼吸运动、解剖变化和小设置不确定性存在时健壮的目标覆盖。在体积调制电弧治疗(VMAT)计划中添加皮肤闪光是一个迭代和手动过程。RapidArc动态(RAD)是一种新的解决方案,它将动态准直器和静态龙门角度调制端口直接集成到电弧输送中。自动皮肤闪光工具(ASF)允许用户直接在优化器中自动添加皮肤闪光。用户必须选择闪光区域的厚度和霍斯菲尔德单位(HUs),但目前还不知道最佳值。对13例左右侧乳腺和胸壁患者,制作了无皮肤闪光、ASF厚度为5 ~ 20mm、HU为-500 ~ 0 HU的RAD平面图。为了评估计划质量,记录计划靶体积(PTV)、心脏、同侧肺、对侧肺和对侧乳房的DVH指标。为了评估计划的稳健性,将等中心移动5毫米,将目标移动到闪光区域前5毫米。记录临床靶体积(CTV) D95%和D99%的变化。采用配对t检验来确定计划质量或稳健性的变化是否具有统计学意义(p≤0.05)。≥7 mm皮肤闪光的增加导致了健壮的计划。改变HU不影响鲁棒性。增加皮肤闪光超过10毫米增加PTV V105%。这一增长在0 HU计划中比在-350 HU计划中要大得多。因此,我们建议使用-350 HU和7-10 mm的皮肤闪光来预测5 mm的碎片间和内部运动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Automatic skin flash optimization in breast and chestwall VMAT with static angle modulated ports: Effect of HU and flash margin size on plan quality and robustness.

Skin flash is typically added to breast and chestwall plans to ensure robust target coverage in the presence of respiratory motion, anatomic changes, and small setup uncertainties. Adding skin flash in volumetric modulated arc therapy (VMAT) plans is an iterative and manual process. RapidArc dynamic (RAD) is a new solution that integrates a dynamic collimator and static-gantry angle modulated ports directly into arc delivery. The automatic skin flash tool (ASF) allows users to automatically add skin flash directly within the optimizer. The user must select the thickness and Hounsfield Units (HUs) of the flash region, but the optimal values are not currently known. For 13 left- and right-sided breast and chestwall patients, RAD plans were created with no skin flash and with ASF with thickness of 5 to 20 mm and HU of -500 to 0 HU. To assess plan quality, DVH metrics for planning target volume (PTV), heart, ipsilateral lung, contralateral lung, and contralateral breast were recorded. To assess plan robustness, the isocenter was shifted 5 mm, moving the target 5 mm anteriorly into the flash region. The changes in clinical target volume (CTV) D95% and D99% were recorded. A paired t-test was used to determine if changes in plan quality or robustness were statistically significant (p ≤ 0.05). The addition of ≥ 7 mm of skin flash resulted in robust plans. Varying the HU did not affect robustness. Increasing the skin flash beyond 10 mm increased PTV V105%. This increase was much larger in the 0 HU plans than in the -350 HU plans. We therefore recommend using -350 HU and 7-10 mm of skin flash for anticipated inter- and intra-fraction motion of 5 mm.

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来源期刊
CiteScore
3.60
自引率
19.00%
发文量
331
审稿时长
3 months
期刊介绍: Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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