人参皂苷CK通过调节P53信号通路促进非小细胞肺癌细胞凋亡

IF 3.5 4区医学 Q2 CHEMISTRY, MEDICINAL

Drug Development Research Pub Date : 2025-02-24 DOI:10.1002/ddr.70050

Xinze Liu, Lin Feng, Xin Jin, Kaijing Sun, Ying Sun, Xinmin Wu, Mingjie Xia, Renbo Tan, Hongmei Yang, Guangzhe Li, Wei Wu, Shuang Zu, Anning Li, Changbao Chen, Xilin Wan

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引用次数: 0

摘要

非小细胞肺癌（NSCLC）是一种发病率和死亡率都很高的恶性肿瘤。人参皂苷具有较强的抗肿瘤活性，可抑制肿瘤细胞生长，促进细胞凋亡。本文通过CCK8、集落形成实验、流式细胞术、荧光染色实验、Western Blot等方法研究了人参皂苷CK对NSCLC 95D和NCI-H460细胞增殖和凋亡的影响，发现人参皂苷CK能够显著抑制非小细胞肺癌的生长和增殖，并明确其作用机制是通过线粒体凋亡途径实现的。为肺癌等重大肿瘤疾病的治疗提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Ginsenoside CK Promotes Cell Apoptosis via Regulating P53 Signal Pathway in Non-Small Cell Lung Cancer

Non-small cell lung cancer (NSCLC) is a malignant tumor with high morbidity and mortality. Ginsenosides have been shown to have strong antitumor activity, inhibiting tumor cell growth and promoting apoptosis. In this paper, the effects of ginsenoside CK on the proliferation and apoptosis of NSCLC 95D and NCI-H460 cells were investigated by CCK8, colony formation assay, flow cytometry, fluorescence staining assay, and Western Blot, and it was found that ginsenoside CK could significantly inhibit the growth and proliferation of non-small cell lung cancer, and it was also clarified that the mechanism of its action was realized by the mitochondrial apoptosis pathway. It provides new therapeutic ideas for lung cancer and other major tumor diseases.

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来源期刊

Drug Development Research 医学-药学

CiteScore

6.40

自引率

2.60%

发文量

104

审稿时长

6-12 weeks

期刊介绍： Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.