Prediction and detection of terminal diseases using Internet of Medical Things: A review

The integration of Artificial Intelligence (AI) with the Internet of Medical Things (IoMT) has revolutionized disease prediction and detection, but challenges such as data heterogeneity, privacy concerns, and model generalizability hinder its full potential in healthcare. This review examines these challenges and evaluates the effectiveness of AI-IoMT techniques in predicting chronic and terminal diseases, including cardiovascular conditions, Alzheimer’s disease, and cancers. We analyze a range of Machine Learning (ML) and Deep Learning (DL) approaches (e.g., XGBoost, Random Forest, CNN, LSTM), alongside advanced strategies like federated learning, transfer learning, and blockchain, to improve model robustness, data security, and interoperability. Findings highlight that transfer learning and ensemble methods enhance model adaptability across clinical settings, while blockchain and federated learning effectively address privacy and data standardization. Ultimately, the review emphasizes the importance of data harmonization, secure frameworks, and multi-disease models as critical research directions for scalable, comprehensive AI-IoMT solutions in healthcare.