高频外周磁刺激治疗卒中后持续性呃逆的疗效：一项回顾性研究。

IF 2 4区医学 Q3 NEUROSCIENCES

Journal of Stroke & Cerebrovascular Diseases Pub Date : 2025-02-18 DOI:10.1016/j.jstrokecerebrovasdis.2025.108262

Fengxia Zhang , Yuexiu Lei , Zhan Zhang

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引用次数: 0

摘要

背景：本研究回顾性评价外周磁刺激治疗脑卒中后持续性呃嗝的疗效和安全性。方法：回顾性分析2022年5月至2023年8月武汉大学人民医院康复医学科收治的脑卒中后持续性呃逆患者，将其分为两组。实验组以膈神经为目标，接受10 Hz外周磁刺激，对照组每日肌内注射甲氧氯普胺10 mg。比较两组患者3天治疗效果、治疗前后打嗝评分及整体临床疗效。结果：17例卒中后持续性打嗝患者纳入研究，其中对照组9例，实验组8例。两组在打嗝次数、打嗝评分或治疗前年龄方面没有显著差异。治疗3 d后，对照组的临床有效率为55.56%，实验组为100% （P=0.01）。对照组3例患者出现不良反应，实验组无不良反应（P=0.036）。结论：对于顽固性脑卒中后呃逆患者，高频外周磁刺激可能比注射甲氧氯普胺更有效，副作用更少。我们的研究结果提出了一种新的治疗策略来治疗中风后持续打嗝。

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Efficacy of high-frequency peripheral magnetic stimulation in treating patients with persistent hiccups post-stroke: A retrospective study

Background

This study retrospectively evaluated the efficacy and safety of peripheral magnetic stimulation for treating persistent hiccups in patients after stroke.

Methods

In this retrospective study, we categorized patients with persistent hiccups post-stroke admitted to the Rehabilitation Medicine Department of Wuhan University People's Hospital between May 2022 to August 2023 into two groups. The experimental group received 10 Hz peripheral magnetic stimulation targeting the phrenic nerve, whereas the control group received a daily intramuscular injection of 10 mg metoclopramide. Treatment efficacy over a 3-day period, hiccup scores before and after treatment, and overall clinical efficacy were compared between the two groups.

Results

Seventeen patients diagnosed with persistent hiccups post-stroke were included, with nine in the control group and eight in the experimental group. There were no significant differences between the two groups in terms of the number of hiccups, hiccup scores, or age prior to treatment. After 3 days of treatment, the clinical efficacy was 55.56 % for the control group and 100 % for the experimental group (P = 0.01). Three patients in the control group experienced adverse reactions, whereas no adverse reactions were observed in the experimental group (P = 0.036).

Conclusions

High-frequency peripheral magnetic stimulation may be more effective and associated with fewer adverse effects than metoclopramide injections for patients with intractable post-stroke hiccups. Our findings suggest a novel therapeutic strategy for managing persistent hiccups following a stroke.

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来源期刊

Journal of Stroke & Cerebrovascular Diseases Medicine-Surgery

CiteScore

5.00

自引率

4.00%

发文量

583

审稿时长

62 days

期刊介绍： The Journal of Stroke & Cerebrovascular Diseases publishes original papers on basic and clinical science related to the fields of stroke and cerebrovascular diseases. The Journal also features review articles, controversies, methods and technical notes, selected case reports and other original articles of special nature. Its editorial mission is to focus on prevention and repair of cerebrovascular disease. Clinical papers emphasize medical and surgical aspects of stroke, clinical trials and design, epidemiology, stroke care delivery systems and outcomes, imaging sciences and rehabilitation of stroke. The Journal will be of special interest to specialists involved in caring for patients with cerebrovascular disease, including neurologists, neurosurgeons and cardiologists.