利用冥想研究来研究迷幻药相关的副作用。

IF 3.7 4区 医学 Q1 PSYCHIATRY
International Review of Psychiatry Pub Date : 2024-12-01 Epub Date: 2024-11-13 DOI:10.1080/09540261.2024.2420745
Roman Palitsky, Nicholas K Canby, Nicholas T Van Dam, Holly F Levin-Aspenson, Deanna M Kaplan, Jessica Maples-Keller, Charles L Raison, George H Grant, Boadie W Dunlop, Willoughby B Britton
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引用次数: 0

摘要

在现有的研究中,致幻剂已经显示出一系列益处和低危害的早期证据。然而,致幻剂的不良反应(AE)研究一直受到限制,导致AE特征不明确,测量不一致,并且可能低估AE。开发安全、有效的致幻剂疗法和对发生不良事件的治疗方法,需要对致幻剂相关的不良事件、其现象、危险因素和纵向持续时间进行全面评估。冥想相关事件的研究在许多重要方面与迷幻相关事件的现象学和语境特征重叠,这对迷幻相关事件的研究提出了许多方法上的挑战。因此,与冥想相关的AE研究为迷幻AE研究提供了有价值的主题和方法见解。本文对致幻剂和冥想中现有的AE研究进行了综合综述,并提出了利用冥想研究来推进致幻剂AE研究的议程。这包括将冥想相关的ae作为迷幻相关ae的比较条件,以及采用以下建议:(1)详细和全面的,(2)用户知情的,(3)基于影响的,(4)标准化的,(5)无偏倚的,(6)具有代表性的ae测量和(7)检查影响其影响和轨迹的因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Leveraging meditation research for the study of psychedelic-related adverse effects.

Psychedelics have shown early evidence for a range of benefits and low harm profiles in extant research. However, adverse effects (AEs) research in psychedelics has been limited, leading to underspecified AE profiles, inconsistent measurement, and potential undercounting of AEs. The development of safe, effective psychedelic therapies and treatments for AEs when they occur requires a thorough assessment of psychedelic-related AEs, their phenomenology, risk factors, and longitudinal duration. This article proposes that research on meditation-related AEs, which overlap in important ways with the phenomenological and contextual characteristics of psychedelic-related AEs, has engaged many methodological challenges present in the study of psychedelic-related AEs. Thus, meditation-related AE research offers thematic and methodological insights that are valuable to psychedelic AE research. An integrative review of extant AE research in both psychedelics and meditation is provided, and an agenda for leveraging meditation research to advance the investigation of psychedelic AEs is recommended. This includes the utility of meditation-related AEs as a comparator condition for psychedelic-related AEs, as well as recommendations for the adoption of (1) detailed and comprehensive, (2) user-informed, (3) impact-based, (4) standardized, (5) unbiased, and (6) representative measures of AEs and (7) examining factors that influence their impacts and trajectories.

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来源期刊
CiteScore
5.10
自引率
0.00%
发文量
85
期刊介绍: The International Review of Psychiatry is the premier review journal in the field with a truly international authorship and readership. Each bimonthly issue is dedicated to a specific theme relevant to psychiatry, edited by recognized experts on the topic, who are selected by the Editors and the Editorial Board. Each issue provides in-depth, scholarly reviews of the topic in focus. The Journal reaches a broad international readership including clinicians, academics, educators, and researchers who wish to remain up-to-date with recent and rapid developments in various fields of psychiatry. It aims to be of value to trainees by choosing topics of relevance to career development, which are also suitable for clinicians for continuing professional development.
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