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IF 2.7 Q2 PATHOLOGY

Pathophysiology Pub Date : 2025-02-02 DOI:10.3390/pathophysiology32010007

Shalan Alaamri, Abdulhalim S Serafi, Zahir Hussain, Shouq K Bafail, Mohammed A Bafail, Lusine Demirkhanyan, Christopher S Gondi, Sumera Sohail

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引用次数: 0

摘要

背景/目的：高血压（HT）的主要病因之一是人群从正常体重（NW）状态转变为超重（OW）状态和肥胖，从而导致心血管疾病（CVD）和其他疾病。高血压和超重相关高血压（OW-related hypertension，OHT）的发病涉及多种因素/变量。然而，我们计划研究血清瘦素（Lep）、肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、总胆固醇（TC）和血清睾酮（ST）在中年男性 OHT 中的病理生理作用：我们咨询了三组中年男性（年龄：51-60 岁）--HT 组（97 人，体重高度正常（HNW），体重指数（BMI）：23-24.9 kg/m2）；OHT 组（97 人，体重高度超重（HOW），体重指数（BMI）：28-29.9 kg/m2）和正常对照组（NC，98 人，体重高度正常）--来研究 Lep、IL-6、TNF-α、ST、TC 及其他变量的变化和相关性：结果：在患者组中，TNF-α、Lep、ST 和 TC 的比较结果有显著差异。OHT与NC相比，ST有显著差异。OHT与NC以及OHT与HT在IL-6方面存在显著差异。各组间血清中 TNF-α、Lep、IL-6、ST 和 TC 的水平均有显著变化。TNF-α、Lep、TC 和 IL-6 呈显著正线性相关。ST与Lep、TNF-α和IL-6呈显著负线性关系：本报告提供了病理生理学证据，证明在患有 HT 和 OHT 的中年男性中，血清 Lep、TNF-α、ST、TC 和 IL-6 起着交互作用。我们认为，本研究中注意到的变化将有助于对患有/不患有 HT 的 NW、OW 和肥胖受试者的不同亚类进行基于 BMI 的进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Overweight-Related Hypertension in Middle-Aged Men Is Linked to Elevated Leptin, TNF-α, IL-6, Cholesterol, and Reduced Testosterone.

Background/objectives: One of the major causes of hypertension (HT) is the transition of normal weight (NW) status to overweight (OW) status and obesity in a population, which leads to cardiovascular disease (CVD) and other disorders. A variety of factors/variables are involved in the development of HT and OW-related hypertension (OHT). However, we planned to investigate the pathophysiological role of serum leptin (Lep), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), total cholesterol (TC) and serum testosterone (ST) in OHT in middle-aged men.

Methods: We consulted three groups of middle-aged men (age: 51-60 years)-an HT group (n: 97, high normal weight (HNW), body mass index (BMI): 23-24.9 kg/m²); an OHT group (n: 97, high overweight (HOW), BMI: 28-29.9 kg/m²) and a normal control group (NC, n: 98, HNW)-to investigate the variations in and correlations of Lep, IL-6, TNF-α, ST, TC and other variables.

Results: Significant variations were obtained for the comparisons of TNF-α, Lep, ST and TC for the patient groups. OHT vs. NC showed a significant difference for ST. OHT vs. NC and OHT vs. HT had significant variations for IL-6. Significant changes were obtained for the serum levels of TNF-α, Lep, IL-6, ST and TC among groups. Significant and positive linear associations were obtained for TNF-α, Lep, TC and IL-6. Significant and negative linear associations were found for ST plotted against Lep, TNF-α and IL-6.

Conclusions: The current report provides pathophysiological evidence of the interactive role of serum Lep, TNF-α, ST, TC and IL-6 in middle-aged men with HT and OHT. We suggest that the changes we noted in the present study would be helpful for further BMI-based studies in various subcategories of NW, OW and obese subjects with/without HT.

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来源期刊

Pathophysiology Medicine-Pathology and Forensic Medicine

CiteScore

3.10

自引率

0.00%

发文量

期刊介绍： Pathophysiology is an international journal which publishes papers in English which address the etiology, development, and elimination of pathological processes. Contributions on the basic mechanisms underlying these processes, model systems and interdisciplinary approaches are strongly encouraged.