癌症中的乳化作用：代谢机制和治疗策略。

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-02-20 DOI:10.1038/s41420-025-02349-4

Ying Sui, Ziyang Shen, Zhenling Wang, Jifeng Feng, Guoren Zhou

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引用次数: 0

摘要

癌症代谢研究的最新进展表明，乳酸化是影响肿瘤发生和发展的一种关键的翻译后修饰。这一过程依赖于乳酸的积累和对乳酸敏感的酰基转移酶的激活。除了在表观遗传调控中的作用外，乳酸化已成为肿瘤代谢和进化中的一个重要因素，为开发超越传统方法的靶向疗法提供了新的机遇。这篇综述探讨了乳酰化在癌症生物学中日益增长的重要性，并强调了乳酰化在推进诊断工具和治疗策略方面的潜力。

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Lactylation in cancer: metabolic mechanism and therapeutic strategies.

Recent progress in cancer metabolism research has identified lactylation as a critical post-translational modification influencing tumor development and progression. The process relies on lactate accumulation and the activation of lactate-sensitive acyltransferases. Beyond its role in epigenetic regulation, lactylation has emerged as a significant factor in tumor metabolism and evolution, offering fresh opportunities for developing targeted therapies that transcend traditional approaches. This review explores the growing importance of lactylation in cancer biology and highlights its potential for advancing diagnostic tools and therapeutic strategies.

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.